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Cat. No.: HY-178438

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Mer/c-Met-IN-1

Mer/c-Met-IN-1 is a potent Mer/c-met dual inhibitor with IC₅₀ values of 1 and 19 nM. Mer/c-Met-IN-1 can inhibit cancer cells proliferation, migration and induce apoptosis. Mer/c-Met-IN-1 can be used for the research of cancer, such as colon cancer.

For research use only. We do not sell to patients.

CAS No.: 3062159-91-2
Formula: C₃₈H₃₈FN₇O₄
Molecular Weight:675.75

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Mer/c-Met-IN-1 Chemical Structure

CAS No.: 3062159-91-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

Mer/c-Met-IN-1 exhibits robust antiproliferative activity against HCT116, A2780, and PC-3 cancer cell lines with IC₅₀ values of 1.01 μM, 0.96 μM, and 3.42 μM respectively^[1].
Mer/c-Met-IN-1 shows favorable metabolic stability in human liver microsomes with a half-life (t_1/2) of 72.6 min and a clearance rate (CL) of 0.05 mL/min/mg^[1].
Mer/c-Met-IN-1 exhibits negligible inhibition on hERG potassium channels with an IC₅₀ value >40 μM^[1].
Mer/c-Met-IN-1 (0.4-3.2 μM, 48 h) induces dose-dependent apoptosis in HCT116 cells with an ED₅₀ of 1.368 pM^[1].
Mer/c-Met-IN-1 (0.8-20 μM, 24 h) significantly suppresses the migration of HCT116 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

HCT116 cells
Concentration:

0.4, 0.8, 1.6 and 3.2 μM
Incubation Time:

48 h
Result:

Increased the Tunel-positive cells.

Chemical Information

CAS No. 3062159-91-2
Molecular Weight 675.75
Formula C₃₈H₃₈FN₇O₄
SMILES

CN1CCN(CC1)C2=CC(NC3=NC(OC4=CC=C(C=C4)NC(C5=CN(C=C(C5=O)C6=CC=C(C=C6)F)CC7CCCO7)=O)=CC=N3)=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Duan L, et al. Design, synthesis, and biological evaluation of novel potent dual Mer/c-Met inhibitors based on structural optimization. Bioorg Med Chem Lett. 2025 Sep 20;130:130415. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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