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Cat. No.: HY-187767

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Mitoxantrone carboxylic acid

Mitoxantrone carboxylic acid is the monocarboxylic acid metabolite of the antitumor agent Mitoxantrone (HY-13502). Mitoxantrone carboxylic acid is formed by oxidation of the terminal hydroxyl group on the side chain, and serves as one of the major metabolites in both humans and rabbits, which is mainly excreted via bile. Mitoxantrone carboxylic acid can be used as an HPLC reference marker for pharmacokinetic and metabolic studies of Mitoxantrone.

For research use only. We do not sell to patients.

CAS No.: 97729-56-1
Formula: C₂₂H₂₆N₄O₇
Molecular Weight:458.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Mitoxantrone carboxylic acid Chemical Structure

CAS No.: 97729-56-1

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
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Biological Activity

Description

In Vitro

Mitoxantrone carboxylic acid is the major extracellular metabolite of [¹⁴C] Mitoxantrone in primary cultured rabbit hepatocytes, with an extracellular concentration of 1.28 μM, accounting for 75.0% of the total extracellular radioactive metabolites^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Mitoxantrone carboxylic acid is the major metabolite of [¹⁴C] Mitoxantrone after intravenous administration in rabbits. It is mainly excreted via bile, with biliary excretion accounting for approximately 28-30% of the administered dose, and urinary excretion accounting for approximately 6-7%^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 97729-56-1
Molecular Weight 458.47
Formula C₂₂H₂₆N₄O₇
SMILES

O=C(O)CNCCNC1=CC=C(NCCNCCO)C=2C(=O)C=3C(O)=CC=C(O)C3C(=O)C12
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ehninger G, et al. Detection and separation of mitoxantrone and its metabolites in plasma and urine by high-performance liquid chromatography. Journal of chromatography. 1985 Jul 12;342(1):119-27.

[2]. Richard B, et al. Excretion and metabolism of mitoxantrone in rabbits. Cancer Res. 1989 Feb 15;49(4):833-7. PMID: 2912555.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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