97729-56-1
Chemical Structure
Mitoxantrone carboxylic acid
- CAS No.: 97729-56-1
- Formula:C22H26N4O7
- Molecular Weight:458.47
IUPAC Name: (2-((5,8-dihydroxy-4-((2-((2-hydroxyethyl)amino)ethyl)amino)-9,10-dioxo-9,10-dihydroanthracen-1-yl)amino)ethyl)glycine
InChIKey: ATIAHAUGEJHHNT-UHFFFAOYSA-N
SMILES: O=C(O)CNCCNC1=CC=C(NCCNCCO)C=2C(=O)C=3C(O)=CC=C(O)C3C(=O)C12
Biological Activity: Mitoxantrone carboxylic acid is the monocarboxylic acid metabolite of the antitumor agent Mitoxantrone (HY-13502). Mitoxantrone carboxylic acid is formed by oxidation of the terminal hydroxyl group on the side chain, and serves as one of the major metabolites in both humans and rabbits, which is mainly excreted via bile. Mitoxantrone carboxylic acid can be used as an HPLC reference marker for pharmacokinetic and metabolic studies of Mitoxantrone[1][2].
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Mitoxantrone carboxylic acid | Mitoxantrone carboxylic acid is the monocarboxylic acid metabolite of the antitumor agent Mitoxantrone (HY-13502). Mitoxantrone carboxylic acid is formed by oxidation of the terminal hydroxyl group on the side chain, and serves as one of the major metabolites in both humans and rabbits, which is mainly excreted via bile. Mitoxantrone carboxylic acid can be used as an HPLC reference marker for pharmacokinetic and metabolic studies of Mitoxantrone. | |||||||||||||||||||||
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- [1]. Ehninger G, et al. Detection and separation of mitoxantrone and its metabolites in plasma and urine by high-performance liquid chromatography. Journal of chromatography. 1985 Jul 12;342(1):119-27.
- [2]. Richard B, et al. Excretion and metabolism of mitoxantrone in rabbits. Cancer Res. 1989 Feb 15;49(4):833-7. PMID: 2912555.
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