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Cat. No.: HY-120713

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MK-8325 dihydrochloride

MK-8325 (dihydrochloride) is an inhibitor of HCV NS5A with oral activity. MK-8325 exhibits minimal inhibition on hERG at the concentration of 30 mM.

For research use only. We do not sell to patients.

CAS No.: 1334314-19-0
Formula: C₄₃H₅₄Cl₂F₂N₈O₆Si
Molecular Weight:915.93

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

MK-8325 dihydrochloride Chemical Structure

CAS No.: 1334314-19-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

MK-8325 (dihydrochloride) is an inhibitor of HCV NS5A with oral activity. MK-8325 exhibits minimal inhibition on hERG at the concentration of 30 mM^[1].

Chemical Information

CAS No. 1334314-19-0
Molecular Weight 915.93
Formula C₄₃H₅₄Cl₂F₂N₈O₆Si
SMILES

O=C([C@H](C(C)C)NC(OC)=O)N1C[Si](C[C@H]1C2=NC3=CC=C4C(C=CC(C5=CC=C(C6=CN=C([C@@H]7CC(CN7C([C@H](C(C)C)NC(OC)=O)=O)(F)F)N6)C=C5)=C4)=C3N2)(C)C.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Anilkumar G Nair, et al. MK-8325: A silyl proline-containing NS5A inhibitor with pan-genotype activity for treatment of HCV. Bioorg Med Chem Lett. 2018, 28,10. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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