2. Anti-infection
  3. Bacterial
  4. Mycobacterial Zmp1-IN-1

Mycobacterial Zmp1-IN-1 is a mycobacterial zinc metalloprotease-1 (Zmp1) inhibitor. Mycobacterial Zmp1-IN-1 has anti-mycobacterial activity for Mtb H37Ra in dose-dependent inhibition. Mycobacterial Zmp1-IN-1 can be used for the research of tuberculosis (TB).

For research use only. We do not sell to patients.

Mycobacterial Zmp1-IN-1

Mycobacterial Zmp1-IN-1 Chemical Structure

CAS No. : 3033421-29-0

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Mycobacterial Zmp1-IN-1 Related Antibodies

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Description

Mycobacterial Zmp1-IN-1 is a mycobacterial zinc metalloprotease-1 (Zmp1) inhibitor. Mycobacterial Zmp1-IN-1 has anti-mycobacterial activity for Mtb H37Ra in dose-dependent inhibition. Mycobacterial Zmp1-IN-1 can be used for the research of tuberculosis (TB)[1].

Cellular Effect
Cell Line Type Value Description References
MRC5 IC50
> 128 μM
Compound: 2f
Cytotoxicity against human MRC5 cells assessed as inhibition of cell growth measured after 72 hrs by resazurin staining based microscopic analysis
Cytotoxicity against human MRC5 cells assessed as inhibition of cell growth measured after 72 hrs by resazurin staining based microscopic analysis
[PMID: 36242986]
RAW264.7 IC50
> 128 μM
Compound: 2f
Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell growth measured after 72 hrs by resazurin staining based microscopic analysis
Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell growth measured after 72 hrs by resazurin staining based microscopic analysis
[PMID: 36242986]
In Vitro

Mycobacterial Zmp1-IN-1 (Compound 2f) has antimycobacterial activity for M. bovis and Mtb H37Ra in dose-dependent inhibition[1].
Mycobacterial Zmp1-IN-1 has no acute cellular toxicity against the RAW 264.7 and MRC-5 cell line with IC50 values both of ＞128 μM[1].
Mycobacterial Zmp1-IN-1 (8 μM, 32 μM, 128 μM) induces a reduction of bacterial survival within the macrophage host cell[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mycobacterial Zmp1-IN-1 Related Antibodies
Molecular Weight

525.57

Formula

C26H27N3O7S
CAS No.
SMILES

COC([C@H](C(C)C)NC(C1=CC=C(C=C1)/C=C2SC(N(C\2=O)CC(NOCC3=CC=CC=C3)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Mycobacterial Zmp1-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mycobacterial Zmp1-IN-13033421-29-0Bacterialzinc metalloprotease-1 (Zmp1)anti-mycobacterialH37Ratuberculosis (TB)Inhibitorinhibitorinhibit

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