Mycobacterial Zmp1-IN-1
Mycobacterial Zmp1-IN-1 is a mycobacterial zinc metalloprotease-1 (Zmp1) inhibitor. Mycobacterial Zmp1-IN-1 has anti-mycobacterial activity for Mtb H37Ra in dose-dependent inhibition. Mycobacterial Zmp1-IN-1 can be used for the research of tuberculosis (TB).
For research use only. We do not sell to patients.
- CAS No.: 3033421-29-0
- Formula: C26H27N3O7S
- Molecular Weight:525.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MRC5 | IC50 |
>128 μM
Compound: 2f
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Cytotoxicity against human MRC5 cells assessed as inhibition of cell growth measured after 72 hrs by resazurin staining based microscopic analysis
Cytotoxicity against human MRC5 cells assessed as inhibition of cell growth measured after 72 hrs by resazurin staining based microscopic analysis
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[PMID: 36242986] |
| RAW264.7 | IC50 |
>128 μM
Compound: 2f
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Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell growth measured after 72 hrs by resazurin staining based microscopic analysis
Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell growth measured after 72 hrs by resazurin staining based microscopic analysis
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[PMID: 36242986] |
Mycobacterial Zmp1-IN-1 (Compound 2f) has antimycobacterial activity for M. bovis and Mtb H37Ra in dose-dependent inhibition[1].
Mycobacterial Zmp1-IN-1 has no acute cellular toxicity against the RAW 264.7 and MRC-5 cell line with IC50 values both of ＞128 μM[1].
Mycobacterial Zmp1-IN-1 (8 μM, 32 μM, 128 μM) induces a reduction of bacterial survival within the macrophage host cell[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3033421-29-0
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Molecular Weight 525.57
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Formula C26H27N3O7S
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SMILES
COC([C@H](C(C)C)NC(C1=CC=C(C=C1)/C=C2SC(N(C\2=O)CC(NOCC3=CC=CC=C3)=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mycobacterial Zmp1-IN-1 Related Classifications
HY-152035 Related Classifications
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