2. Metabolic Enzyme/Protease
  3. NAMPT
  4. Nampt-IN-10 trihydrochloride

Nampt-IN-10 trihydrochloride (compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-10 trihydrochloride shows cellular potency to A2780 and CORL23 cell lines with IC50 values of 5 and 19 nM, respectively. Nampt-IN-10 trihydrochloride can be used as a novel non-antimitotic payload for antibody-drug conjugate (ADC).

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Nampt-IN-10 trihydrochloride

Nampt-IN-10 trihydrochloride Estructura química

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Nampt-IN-10 trihydrochloride Related Antibodies

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Descripciòn

Nampt-IN-10 trihydrochloride (compound 4) is a Nicotinamide Phosphoribosyltransferase (NAMPT) inhibitor. Nampt-IN-10 trihydrochloride shows cellular potency to A2780 and CORL23 cell lines with IC50 values of 5 and 19 nM, respectively. Nampt-IN-10 trihydrochloride can be used as a novel non-antimitotic payload for antibody-drug conjugate (ADC)[1].

IC50 & Target

IC50: 5 nM (A2780), 19 nM (CORL23), 2 nM (NCI-H526 with c-Kit expressing), 0.4 nM (MDA-MB453 with HER2 expressing), 1 nM (NCI-N87 with HER2 expressing)[1]
In Vitro

Nampt-IN-10 trihydrochloride (0-1 μM; 72 h) shows cytotoxicity to A2780, CORL23, and c-Kit and HER2 expressing cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nampt-IN-10 trihydrochloride Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: A2780, CORL23, NCI-H526 with c-Kit expressing, MDA-MB453 and NCI-N87 with HER2 expressing cell lines
Concentration: 0-1 μM
Incubation Time: 72 hours
Result: Showed cytotoxicity to A2780, CORL23, NCI-H526 with c-Kit expressing, MDA-MB453 and NCI-N87 with HER2 expressing cells with IC50 values of 5, 19, 2, 0.4 and 1 nM, respectively.
Peso molecular

582.92

Fòrmula

C27H31Cl3FN5O2
SMILES

FC(C=C1NC([C@@H]2[C@@H](C3=CN=CC=C3)C2)=O)=C(C=C1)CNC(C4=CC=C(N5CCNCC5)C=C4)=O.[H]Cl.[H]Cl.[H]Cl
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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Nampt-IN-10 trihydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nampt-IN-10 trihydrochlorideNAMPTNicotinamide phosphoribosyl transferasePBEFVisfatinpre-B cell-enhancing factorPre-B cell colony enhancing factorA2780CORL23NCI-H526MDA-MB453NCI-N87ADCInhibitorinhibitorinhibit

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Inquiry Information

Nombre del producto:
Nampt-IN-10 trihydrochloride
Cat. No.:
HY-147193A
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MCE Japan Authorized Agent:

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