NS2B/NS3-IN-3 dihydrochloride
Based on 1 Customer Validation
NS2B/NS3-IN-3 dihydrochloride is an inhibitor of Flavivirus NS2B-NS3 protease, with an IC50 of 0.32 μM against Zika virus NS2B-NS3 protease. NS2B/NS3-IN-3 dihydrochloride also exhibits inhibitory effects on dengue virus type 2 NS2B-NS3 protease and West Nile virus NS2B-NS3 protease. NS2B/NS3-IN-3 dihydrochloride inhibits the intracellular replication of Zika virus. NS2B/NS3-IN-3 dihydrochloride can be used in studies related to flavivirus infections.
For research use only. We do not sell to patients.
- Formula: C19H23Cl2N3O2
- Molecular Weight:396.31
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
NS2B/NS3-IN-3 (compound 66) dihydrochloride potently inhibits recombinant Zika virus NS2B-NS3 protease with an IC50 of 0.32 μM; it also inhibits recombinant dengue virus type 2 NS2B-NS3 protease with an IC50 of approximately 1-2 μM, and exhibits a non-competitive inhibition mode[1].
NS2B/NS3-IN-3 (1-10 μM; 48 h) dihydrochloride exhibits dose-dependent antiviral activity against Zika virus (strain FLR) in human U87 glioma cells, with an EC68 of 1 μM, and shows no toxicity to U87 cells at a concentration of 10 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 396.31
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Formula C19H23Cl2N3O2
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SMILES
O=C(C(N1)=CC2=C1C=C(C3=COC=C3)C=C2)NCC4CCNCC4.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
H2O : 10 mg/mL (25.23 mM; Need ultrasonic)
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.5233 mL | 12.6164 mL | 25.2328 mL | 63.0819 mL |
| 5 mM | 0.5047 mL | 2.5233 mL | 5.0466 mL | 12.6164 mL | |
| 10 mM | 0.2523 mL | 1.2616 mL | 2.5233 mL | 6.3082 mL | |
| 15 mM | 0.1682 mL | 0.8411 mL | 1.6822 mL | 4.2055 mL | |
| 20 mM | 0.1262 mL | 0.6308 mL | 1.2616 mL | 3.1541 mL | |
| 25 mM | 0.1009 mL | 0.5047 mL | 1.0093 mL | 2.5233 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
NS2B/NS3-IN-3 dihydrochloride Related Classifications
HY-144644B Related Classifications
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