NS2B/NS3-IN-3 dihydrochloride
Based on 1 Customer Validation
NS2B/NS3-IN-3 dihydrochloride is an inhibitor of Flavivirus NS2B-NS3 protease, with an IC50 of 0.32 μM against Zika virus NS2B-NS3 protease. NS2B/NS3-IN-3 dihydrochloride also exhibits inhibitory effects on dengue virus type 2 NS2B-NS3 protease and West Nile virus NS2B-NS3 protease. NS2B/NS3-IN-3 dihydrochloride inhibits the intracellular replication of Zika virus. NS2B/NS3-IN-3 dihydrochloride can be used in studies related to flavivirus infections.
For research use only. We do not sell to patients.
- Purity : 99.26%
- Formula: C19H23Cl2N3O2
- Molecular Weight:396.31
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
NS2B/NS3-IN-3 (compound 66) dihydrochloride potently inhibits recombinant Zika virus NS2B-NS3 protease with an IC50 of 0.32 μM; it also inhibits recombinant dengue virus type 2 NS2B-NS3 protease with an IC50 of approximately 1-2 μM, and exhibits a non-competitive inhibition mode[1].
NS2B/NS3-IN-3 (1-10 μM; 48 h) dihydrochloride exhibits dose-dependent antiviral activity against Zika virus (strain FLR) in human U87 glioma cells, with an EC68 of 1 μM, and shows no toxicity to U87 cells at a concentration of 10 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Molecular Weight 396.31
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Formula C19H23Cl2N3O2
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Color Off-white to light yellow
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SMILES
O=C(C(N1)=CC2=C1C=C(C3=COC=C3)C=C2)NCC4CCNCC4.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
H2O : 10 mg/mL (25.23 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.5233 mL | 12.6164 mL | 25.2328 mL | 63.0819 mL |
| 5 mM | 0.5047 mL | 2.5233 mL | 5.0466 mL | 12.6164 mL | |
| 10 mM | 0.2523 mL | 1.2616 mL | 2.5233 mL | 6.3082 mL | |
| 15 mM | 0.1682 mL | 0.8411 mL | 1.6822 mL | 4.2055 mL | |
| 20 mM | 0.1262 mL | 0.6308 mL | 1.2616 mL | 3.1541 mL | |
| 25 mM | 0.1009 mL | 0.5047 mL | 1.0093 mL | 2.5233 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
NS2B/NS3-IN-3 dihydrochloride Related Classifications
HY-144644B Related Classifications
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