Oxprenolol-d7 hydrochloride
Based on 1 Customer Validation
Oxprenolol-d7 (hydrochloride) is the deuterium labeled Oxprenolol hydrochloride. Oxprenolol hydrochloride (Ba 39089) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle.
For research use only. We do not sell to patients.
- Purity: 98.25%
- CAS No.: 1189649-47-5
- Formula: C15H17D7ClNO3
- Molecular Weight:308.85
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1189649-47-5
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Unlabeled Cas 6452-73-9
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Appearance Solid
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Molecular Weight 308.85
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Formula C15H17D7ClNO3
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Color White to off-white
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SMILES
[2H]C([2H])([2H])C(C([2H])([2H])[2H])([2H])NCC(O)COC1=C(C=CC=C1)OCC=C.Cl[H]
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Synonyms
Ba 39089-d7
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (323.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. T Nagatomo, et al. Binding Characteristics of 3H-dihydroalprenolol to Beta-Adrenoceptors of Rat Heart Treated With Neuraminidase. Jpn J Pharmacol. 1983 Aug;33(4):851-7. [Content Brief]
[3]. A S Manning, et al. Abrupt Withdrawal of Chronic Beta-Blockade: Adaptive Changes in Cyclic AMP and Contractility. J Mol Cell Cardiol. 1981 Nov;13(11):999-1009. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.2378 mL | 16.1891 mL | 32.3782 mL | 80.9454 mL |
| 5 mM | 0.6476 mL | 3.2378 mL | 6.4756 mL | 16.1891 mL | |
| 10 mM | 0.3238 mL | 1.6189 mL | 3.2378 mL | 8.0945 mL | |
| 15 mM | 0.2159 mL | 1.0793 mL | 2.1585 mL | 5.3964 mL | |
| 20 mM | 0.1619 mL | 0.8095 mL | 1.6189 mL | 4.0473 mL | |
| 25 mM | 0.1295 mL | 0.6476 mL | 1.2951 mL | 3.2378 mL | |
| 30 mM | 0.1079 mL | 0.5396 mL | 1.0793 mL | 2.6982 mL | |
| 40 mM | 0.0809 mL | 0.4047 mL | 0.8095 mL | 2.0236 mL | |
| 50 mM | 0.0648 mL | 0.3238 mL | 0.6476 mL | 1.6189 mL | |
| 60 mM | 0.0540 mL | 0.2698 mL | 0.5396 mL | 1.3491 mL | |
| 80 mM | 0.0405 mL | 0.2024 mL | 0.4047 mL | 1.0118 mL | |
| 100 mM | 0.0324 mL | 0.1619 mL | 0.3238 mL | 0.8095 mL |
Oxprenolol-d7 hydrochloride Related Classifications
HY-B1486S Related Classifications
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