1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Oxprenolol hydrochloride

Oxprenolol hydrochloride (Synonyms: Ba 39089)

Cat. No.: HY-B1486 Purity: 99.86%
Handling Instructions

Oxprenolol hydrochloride (Ba 39089) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle.

For research use only. We do not sell to patients.

Oxprenolol hydrochloride Chemical Structure

Oxprenolol hydrochloride Chemical Structure

CAS No. : 6452-73-9

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
100 mg USD 150 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Oxprenolol hydrochloride (Ba 39089) is an orally bioavailable β-adrenergic receptor (β-AR) antagonist with a Ki of 7.10 nM in a radioligand binding assay using rat heart muscle[1].

IC50 & Target

Ki: 7.10 nM (β-adrenergic receptor)[1]

In Vivo

Oxprenolol (200 mg/kg/day; administered orally; for 3 weeks) produces effective beta-blockade[2].

Animal Model: Male rats (230 to 300 g body wt) of the Wistar strain[2]
Dosage: 200 mg/kg
Administration: Administered orally; daily for 3 weeks
Result: This dosage produced effective beta-blockade.
Molecular Weight

301.81

Formula

C₁₅H₂₄ClNO₃

CAS No.

6452-73-9

SMILES

OC(COC1=CC=CC=C1OCC=C)CNC(C)C.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (828.34 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3133 mL 16.5667 mL 33.1334 mL
5 mM 0.6627 mL 3.3133 mL 6.6267 mL
10 mM 0.3313 mL 1.6567 mL 3.3133 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.89 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (6.89 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (6.89 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

OxprenololBa 39089Ba39089Ba-39089Adrenergic ReceptorBeta Receptorheartdisease anginahypertensionarrhythmiahighbloodpressureheartbeatsInhibitorinhibitorinhibit

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Product name:
Oxprenolol hydrochloride
Cat. No.:
HY-B1486
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