1. GPCR/G Protein Neuronal Signaling
  2. Melanocortin Receptor
  3. (p-Iodo-Phe7)-ACTH (4-10)

(p-Iodo-Phe7)-ACTH (4-10) is a adrenocorticotrophic hormone (ACTH) derivative, which is produced and secreted by the anterior pituitary gland. (p-Iodo-Phe7)-ACTH (4-10) serves as a melanocortin (MC) receptor antagonist and inhibits α-melanocyte-stimulating hormone (α-MSH)-induced excessive grooming behavior in rats.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

(p-Iodo-Phe7)-ACTH (4-10) Chemical Structure

(p-Iodo-Phe7)-ACTH (4-10) Chemical Structure

CAS No. : 159600-82-5

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

(p-Iodo-Phe7)-ACTH (4-10) is a adrenocorticotrophic hormone (ACTH) derivative, which is produced and secreted by the anterior pituitary gland. (p-Iodo-Phe7)-ACTH (4-10) serves as a melanocortin (MC) receptor antagonist and inhibits α-melanocyte-stimulating hormone (α-MSH)-induced excessive grooming behavior in rats[1].

In Vitro

(p-Iodo-Phe7)-ACTH (4-10) (1 μM) exhibits inhibition of α-MSH-induced (1 nM-1 μM) cAMP accumulation in 293 HEK cells expressing either the rat melanocortin MC3, human melanocortin MC4 or ovine melanocortin MC5 receptor[1].
[Phe-I7]ACTH(4-10) has higher affinity for the MC3, MC4, and MC5 receptors but lower for the MC1 compared to ACTH(4-10)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

(p-Iodo-Phe7)-ACTH (4-10) (15 μg per animal; i.c.v.; single dose) blocks the a-MSH-induced excessive grooming behavior in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (150 g)[1]
Dosage: 1.5 or 15 μg per animal, mixed with 1.5 μg α-MSH or not
Administration: Intracerebroventricular injection; one week prior to the experiment
Result: Didn’t induce excessive grooming behavior by single dose.
Inhibited the induction of excessive grooming behavior by a-MSH.
Molecular Weight

1087.98

Formula

C44H58IN13O10S

CAS No.
Sequence Shortening

MEH-{p-Iodo-Phe}-RWG

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

(p-Iodo-Phe7)-ACTH (4-10) Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
(p-Iodo-Phe7)-ACTH (4-10)
Cat. No.:
HY-P3567
Quantity:
MCE Japan Authorized Agent: