(p-Iodo-Phe7)-ACTH (4-10)
(p-Iodo-Phe7)-ACTH (4-10) is a adrenocorticotrophic hormone (ACTH) derivative, which is produced and secreted by the anterior pituitary gland. (p-Iodo-Phe7)-ACTH (4-10) serves as a melanocortin (MC) receptor antagonist and inhibits α-melanocyte-stimulating hormone (α-MSH)-induced excessive grooming behavior in rats.
For research use only. We do not sell to patients.
- CAS No.: 159600-82-5
- Formula: C44H58IN13O10S
- Molecular Weight:1087.98
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
(p-Iodo-Phe7)-ACTH (4-10) (1 μM) exhibits inhibition of α-MSH-induced (1 nM-1 μM) cAMP accumulation in 293 HEK cells expressing either the rat melanocortin MC3, human melanocortin MC4 or ovine melanocortin MC5 receptor[1].
[Phe-I7]ACTH(4-10) has higher affinity for the MC3, MC4, and MC5 receptors but lower for the MC1 compared to ACTH(4-10)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats (150 g)[1]
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Dosage:1.5 or 15 μg per animal, mixed with 1.5 μg α-MSH or not
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Administration:Intracerebroventricular injection; one week prior to the experiment
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Result:Didn’t induce excessive grooming behavior by single dose.
Inhibited the induction of excessive grooming behavior by a-MSH.
Chemical Information
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CAS No. 159600-82-5
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Molecular Weight 1087.98
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Formula C44H58IN13O10S
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Sequence Shortening
MEH-{p-Iodo-Phe}-RWG
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Adan RA, et al. Identification of antagonists for melanocortin MC3, MC4 and MC5 receptors. Eur J Pharmacol. 1994 Nov 15;269(3):331-7. [Content Brief]
[2]. Schiöth HB, et al. Selectivity of [Phe-I7], [Ala6], and [D-Ala4,Gln5,Tyr6] substituted ACTH(4-10) analogues for the melanocortin receptors. Peptides. 1997;18(5):761-3. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(p-Iodo-Phe7)-ACTH (4-10) Related Classifications
HY-P3567 Related Classifications
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