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Cat. No.: HY-182237

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Palmitoyl glutathione

(Synonyms: PGSH)

Palmitoyl glutathione (PGSH) is a palmitoylated peptide derivative and a liver-targeted liposome-forming agent. Palmitoyl glutathione can form liposome-like vesicles with cholesterol, which can encapsulate water-soluble solutes. Palmitoyl glutathione can be used in studies related to Acetaminophen (HY-66005)-induced liver necrosis.

For research use only. We do not sell to patients.

CAS No.: 110995-58-9
Formula: C₂₆H₄₇N₃O₇S
Molecular Weight:545.73

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Palmitoyl glutathione Chemical Structure

CAS No.: 110995-58-9

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

In Vitro

Palmitoyl glutathione (60 μmol/mL total lipids; PGSH:cholesterol molar ratio 2:1) forms stable lamellar liposome-like structures with cholesterol, achieving a [¹⁴C]sucrose encapsulation ratio of 14.9%, while no functional encapsulation occurs without cholesterol^[1].
Palmitoyl glutathione (formulated with cholesterol at 2:1 molar ratio; up to 2 h, 37 °C) liposomes exhibit stability in fresh rat plasma at 37 °C comparable to conventional phosphatidylcholine liposomes, retaining over 80% of encapsulated marker after 2 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Palmitoyl glutathione (30 μmol total lipids per rat; i.v.; single bolus injection) administered to male Wistar rats show rapid blood clearance, high liver accumulation (67.42% of injected dose at 4 hours), low accumulation in spleen, kidneys, and lungs^[1].
Palmitoyl glutathione (81.8 mg/kg; i.v.; single bolus injection) formulated with phosphatidylcholine, administered to male ddY mice 30 minutes before acetaminophen challenge, significantly suppresses Acetaminophen-induced plasma GOT elevation with a mean absorbance of 0.496^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 110995-58-9
Molecular Weight 545.73
Formula C₂₆H₄₇N₃O₇S
SMILES

OC(CNC([C@H](CS)NC(CC[C@@H](C(O)=O)NC(CCCCCCCCCCCCCCC)=O)=O)=O)=O
Synonyms

PGSH
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Kiwada H,et al. Application of synthetic liposomes based on acyl amino acids or acyl peptides as drug carriers. I. Their preparation and transport of glutathione into the liver. Chem Pharm Bull (Tokyo). 1987 Jul;35(7):2935-42. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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