PD-1/PD-L1-IN-39
PD-1/PD-L1-IN-39 (X 14) is an orally active PD-1/PD-L1 inhibitor with a IC50 value of 15.73 nM. PD-1/ PD-L1-in-39 has a good binding affinity for human and mouse PD-L1, with KD values of 14.62 nM and 392 nM, respectively. PD-1/PD-L1-IN-39 has antitumor activity.
For research use only. We do not sell to patients.
- CAS No.: 3032270-35-9
- Formula: C23H20ClFN2O3
- Molecular Weight:426.87
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| 4T1 | IC50 |
77.51 μM
Compound: X14
|
Antiproliferative activity against mouse 4T1 cells as cell killing incubated for 6 days by CCK-8 assay
Antiproliferative activity against mouse 4T1 cells as cell killing incubated for 6 days by CCK-8 assay
|
[PMID: 38348878] |
| Jurkat | IC50 |
53.86 μM
Compound: X14
|
Antiproliferative activity against human Jurkat cells as cell killing incubated for 6 days by CCK-8 assay
Antiproliferative activity against human Jurkat cells as cell killing incubated for 6 days by CCK-8 assay
|
[PMID: 38348878] |
| MDA-MB-231 | IC50 |
15.42 μM
Compound: X14
|
Antiproliferative activity against human MDA-MB-231 cells as cell killing incubated for 6 days by CCK-8 assay
Antiproliferative activity against human MDA-MB-231 cells as cell killing incubated for 6 days by CCK-8 assay
|
[PMID: 38348878] |
Chemical Information
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CAS No. 3032270-35-9
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Molecular Weight 426.87
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Formula C23H20ClFN2O3
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SMILES
ClC1=C(C=CC=C1C2=C(C=CC=C2)F)COC3=NC4=C(C=C3)CN(CC(O)=O)CC4
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)