2. Metabolic Enzyme/Protease
  3. HIF/HIF Prolyl-Hydroxylase
  4. PHD-IN-3

PHD-IN-3 (Compound 15) is an orally active PHD inhibitor. PHD-IN-3 can be used in the study of anemia associated with chronic kidney disease.

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PHD-IN-3

PHD-IN-3 화학구조

CAS No. : 2924181-77-9

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PHD-IN-3 Related Antibodies

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HIF-1α HIF

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제품 설명

PHD-IN-3 (Compound 15) is an orally active PHD inhibitor. PHD-IN-3 can be used in the study of anemia associated with chronic kidney disease[1].

Cellular Effect
Cell Line Type Value Description References
Hep 3B2 EC50
5 μM
Compound: 15
Upregulation of total HIF-1alpha level in human Hep3B cells incubated for 6 hrs by Western blot analysis
Upregulation of total HIF-1alpha level in human Hep3B cells incubated for 6 hrs by Western blot analysis
[PMID: 38189253]
Hep 3B2 EC50
6.8 μM
Compound: 15
Induction of EPO production in human Hep3B cells incubated for 24 hrs by ELISA
Induction of EPO production in human Hep3B cells incubated for 24 hrs by ELISA
[PMID: 38189253]
Hep 3B2 EC50
9 μM
Compound: 15
Upregulation of total HIF-2alpha level in human Hep3B cells incubated for 6 hrs by Western blot analysis
Upregulation of total HIF-2alpha level in human Hep3B cells incubated for 6 hrs by Western blot analysis
[PMID: 38189253]
Hep 3B2 IC50
> 100 μM
Compound: 15
Cytotoxicity against human Hep3B cells by CellTiter-Glo assay
Cytotoxicity against human Hep3B cells by CellTiter-Glo assay
[PMID: 38189253]
분자량

390.40

화학식

C20H18N6O3
CAS No.
SMILES

O[C@@H]1CCN(C1)C2=NC3=C(C(O)=C(N=C3)C(NCC4=CN=C(C=C4)C#N)=O)C=C2
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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PHD-IN-3 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PHD-IN-32924181-77-9HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHPHDInhibitorAnemia5/6 nephrectomy rat disease modelinhibitorinhibit

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상품명:
PHD-IN-3
Cat. No.:
HY-163148
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