Photosensitizer-10
Photosensitizer-10 is a glutathione (GSH)-activatable photosensitizer. Photosensitizer-10 shows minimal photoactivity in the absence of glutathione, and generates a highly active species upon reaction with glutathione to induce photo-cytotoxicity. Photosensitizer-10 exhibits selective photo-cytotoxicity toward cancer cells with elevated intracellular glutathione levels while sparing normal cells. Photosensitizer-10 can be used for the research of cancer, such as lung carcinoma and skin carcinoma.
For research use only. We do not sell to patients.
- Formula: C22H13N3O10S
- Molecular Weight:511.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Photosensitizer-10 (Compound 3) (100 μM) shows reduced absorbance at 470 nm, limiting excitation to the singlet excited state and suppressing photo-induced reactive oxygen species (ROS) formation[1].
Photosensitizer-10 (3-100 μM; 2 h) shows negligible photo-induced degradation of BSA[1].
Photosensitizer-10 (1-10 μM; 24 h) shows selective photo-cytotoxicity toward GSH-overexpressing A549 and A431 cancer cells, while sparing normal WI-38 fibroblasts[1].
Photosensitizer-10 can release the active substance Compound 2 after being activated by GSH[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 human lung carcinoma cells, A431 human squamous carcinoma cells, WI-38 human lung fibroblasts
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Concentration:1, 3, 10 μM
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Incubation Time:15 min (light irradiation); 24 h (post-irradiation incubation)
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Result:Exhibited no dark toxicity across all tested cell lines.
Upon light irradiation, induced dose-dependent cytotoxicity in A549 and A431 cancer cells, while WI-38 normal fibroblasts remained largely unaffected.
At 10 μM, reduced cell viability to ~20% in A549 cells and ~15% in A431 cells, but kept viability near 100% in WI-38 cells.
Chemical Information
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Molecular Weight 511.42
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Formula C22H13N3O10S
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SMILES
O=C(C(C=CC=C1)=C1C2=O)C3=C2C(NC(C)=O)=CC=C3OS(C4=CC=C([N+]([O-])=O)C=C4[N+]([O-])=O)(=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Photosensitizer-10 Related Classifications
HY-182785 Related Classifications
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