2. Apoptosis
  3. Photosensitizer
  4. Photosensitizer-10

Photosensitizer-10 is a glutathione (GSH)-activatable photosensitizer. Photosensitizer-10 shows minimal photoactivity in the absence of glutathione, and generates a highly active species upon reaction with glutathione to induce photo-cytotoxicity. Photosensitizer-10 exhibits selective photo-cytotoxicity toward cancer cells with elevated intracellular glutathione levels while sparing normal cells. Photosensitizer-10 can be used for the research of cancer, such as lung carcinoma and skin carcinoma.

For research use only. We do not sell to patients.

Photosensitizer-10

Photosensitizer-10 Chemical Structure

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Photosensitizer-10 Related Antibodies

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Description

Photosensitizer-10 is a glutathione (GSH)-activatable photosensitizer. Photosensitizer-10 shows minimal photoactivity in the absence of glutathione, and generates a highly active species upon reaction with glutathione to induce photo-cytotoxicity. Photosensitizer-10 exhibits selective photo-cytotoxicity toward cancer cells with elevated intracellular glutathione levels while sparing normal cells. Photosensitizer-10 can be used for the research of cancer, such as lung carcinoma and skin carcinoma[1].

In Vitro

Photosensitizer-10 (Compound 3) (100 μM) shows reduced absorbance at 470 nm, limiting excitation to the singlet excited state and suppressing photo-induced reactive oxygen species (ROS) formation[1].
Photosensitizer-10 (3-100 μM; 2 h) shows negligible photo-induced degradation of BSA[1].
Photosensitizer-10 (1-10 μM; 24 h) shows selective photo-cytotoxicity toward GSH-overexpressing A549 and A431 cancer cells, while sparing normal WI-38 fibroblasts[1].
Photosensitizer-10 can release the active substance Compound 2 after being activated by GSH[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Photosensitizer-10 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: A549 human lung carcinoma cells, A431 human squamous carcinoma cells, WI-38 human lung fibroblasts
Concentration: 1, 3, 10 μM
Incubation Time: 15 min (light irradiation); 24 h (post-irradiation incubation)
Result: Exhibited no dark toxicity across all tested cell lines.
Upon light irradiation, induced dose-dependent cytotoxicity in A549 and A431 cancer cells, while WI-38 normal fibroblasts remained largely unaffected.
At 10 μM, reduced cell viability to ~20% in A549 cells and ~15% in A431 cells, but kept viability near 100% in WI-38 cells.
Molecular Weight

511.42

Formula

C22H13N3O10S
SMILES

O=C(C(C=CC=C1)=C1C2=O)C3=C2C(NC(C)=O)=CC=C3OS(C4=CC=C([N+]([O-])=O)C=C4[N+]([O-])=O)(=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Photosensitizer-10 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Photosensitizer-10Photosensitizer10Photosensitizer 10Photosensitizerglutathionereactive oxygen speciescancer cellssinglet oxygennormal cellsWI-38 fibroblastsA549lung carcinomaskin carcinomaA431Inhibitorinhibitorinhibit

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