1. PI3K/Akt/mTOR
    Apoptosis
  2. PI3K
    Akt
    Apoptosis
  3. PI3Kδ-IN-11

PI3Kδ-IN-11 

Cat. No.: HY-143472
Handling Instructions

PI3Kδ-IN-11 is a highly potent and selective PI3Kδ inhibitor with IC50 value of 27.5 nM. PI3Kδ-IN-11 dose-dependently blocks the activity of PI3K/Akt pathway. PI3Kδ-IN-11 can be used for researching B or T cell-related malignancies.

For research use only. We do not sell to patients.

PI3Kδ-IN-11 Chemical Structure

PI3Kδ-IN-11 Chemical Structure

CAS No. : 2413257-51-7

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Description

PI3Kδ-IN-11 is a highly potent and selective PI3Kδ inhibitor with IC50 value of 27.5 nM. PI3Kδ-IN-11 dose-dependently blocks the activity of PI3K/Akt pathway. PI3Kδ-IN-11 can be used for researching B or T cell-related malignancies[1].

IC50 & Target

PI3Kδ

27.5 nM (IC50)

In Vitro

PI3Kδ-IN-11 (compound 15c) (0-10 μM; 48 hours) inhibits Raji and Ramos with IC50s of 8.5 μM and 5.4 μM, respectively[1].
PI3Kδ-IN-11 (0.2-15 μM; 0-48 hours) dampens the proliferation of Raji cells in a dose- and time-dependent manner[1].
PI3Kδ-IN-11 (5 μM; 24 hours) triggers 10.78% apoptosis of cells[1].
PI3Kδ-IN-11 (1-1000 nM; 24 hours) dose-dependently reduces the phosphorylation of Akt (S473)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line: Raji and Ramos[1]
Concentration: 0-10 μM
Incubation Time: 48 hours
Result: Inhibited Raji and Ramos with IC50s of 8.5 μM and 5.4 μM, respectively.

Cell Proliferation Assay

Cell Line: Raji[1]
Concentration: 0.2, 1, 4, 8, 10 and 15 μM
Incubation Time: 0, 12, 24, 36, 48 hours
Result: Dampened the proliferation of Raji cells in a dose- and time-dependent manner.

Apoptosis Analysis

Cell Line: Raji[1]
Concentration: 5 μM
Incubation Time: 24 hours
Result: Triggered 10.78% apoptosis of cells.

Western Blot Analysis

Cell Line: Raji[1]
Concentration: 1, 10, 100, 500 and 1000 nM
Incubation Time: 24 hours
Result: Dose-dependently reduced the phosphorylation of Akt (S473), illustrating that the activity of PI3K/Akt pathway was efficiently blocked.
Molecular Weight

431.49

Formula

C27H21N5O

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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PI3Kδ-IN-11
Cat. No.:
HY-143472
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