Pomalidomide-C3-NHS ester

Cat. No.: HY-148142 Pureté: 98.70%: Fiche technique
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Pomalidomide-C3-NHS ester is a synthesized E3 ligase ligand-linker conjugate, incorporating the Pomalidomide based cereblon ligand and NHS ester linker.

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Pomalidomide-C3-NHS ester Chemical Structure

CAS No. : 2828476-87-3

Size	Stock	Quantité
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtenir un devis
500 mg	Obtenir un devis

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Based on 1 publication(s) in Google Scholar

Recommandations en vedette

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform E3 Ligase Ligand-Linker Conjugates:

Voir toutes les isoformes

von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

Activité biologique
Pureté et documentation
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Description

Pomalidomide-C3-NHS ester is a synthesized E3 ligase ligand-linker conjugate, incorporating the Pomalidomide based cereblon ligand and NHS ester linker.

IC₅₀ & Target

Cereblon

Masse moléculaire

456.41

Formule

C₂₁H₂₀N₄O₈

CAS No.

2828476-87-3

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=C2C=CC=C1NCCCC(ON3C(CCC3=O)=O)=O)N(C4C(NC(CC4)=O)=O)C2=O

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (219.10 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1910 mL	10.9551 mL	21.9101 mL
5 mM	0.4382 mL	2.1910 mL	4.3820 mL
10 mM	0.2191 mL	1.0955 mL	2.1910 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Pureté et documentation

Purity: 98.70%

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Fiche technique (243 KB) SDS (251 KB)

COA (250 KB) HNMR (145 KB) RP-HPLC (169 KB) LCMS (107 KB)

Instruction de manipulation (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1910 mL	10.9551 mL	21.9101 mL	54.7753 mL
	5 mM	0.4382 mL	2.1910 mL	4.3820 mL	10.9551 mL
	10 mM	0.2191 mL	1.0955 mL	2.1910 mL	5.4775 mL
	15 mM	0.1461 mL	0.7303 mL	1.4607 mL	3.6517 mL
	20 mM	0.1096 mL	0.5478 mL	1.0955 mL	2.7388 mL
	25 mM	0.0876 mL	0.4382 mL	0.8764 mL	2.1910 mL
	30 mM	0.0730 mL	0.3652 mL	0.7303 mL	1.8258 mL
	40 mM	0.0548 mL	0.2739 mL	0.5478 mL	1.3694 mL
	50 mM	0.0438 mL	0.2191 mL	0.4382 mL	1.0955 mL
	60 mM	0.0365 mL	0.1826 mL	0.3652 mL	0.9129 mL
	80 mM	0.0274 mL	0.1369 mL	0.2739 mL	0.6847 mL
	100 mM	0.0219 mL	0.1096 mL	0.2191 mL	0.5478 mL