Propargyl-PEG4-sulfonic acid
Based on 1 Customer Validation
Propargyl-PEG4-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG4-sulfonic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 1817735-29-7
- Formula: C11H20O7S
- Molecular Weight:296.34
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Storage:
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTAC Linkers Isoforms
More
Biological Activity
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PEGs |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1817735-29-7
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Appearance Solid
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Molecular Weight 296.34
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Formula C11H20O7S
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Color White to off-white
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SMILES
C#CCOCCOCCOCCOCCS(=O)(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Solvent & Solubility
DMSO : 50 mg/mL (168.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (267 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3745 mL | 16.8725 mL | 33.7450 mL | 84.3626 mL |
| 5 mM | 0.6749 mL | 3.3745 mL | 6.7490 mL | 16.8725 mL | |
| 10 mM | 0.3375 mL | 1.6873 mL | 3.3745 mL | 8.4363 mL | |
| 15 mM | 0.2250 mL | 1.1248 mL | 2.2497 mL | 5.6242 mL | |
| 20 mM | 0.1687 mL | 0.8436 mL | 1.6873 mL | 4.2181 mL | |
| 25 mM | 0.1350 mL | 0.6749 mL | 1.3498 mL | 3.3745 mL | |
| 30 mM | 0.1125 mL | 0.5624 mL | 1.1248 mL | 2.8121 mL | |
| 40 mM | 0.0844 mL | 0.4218 mL | 0.8436 mL | 2.1091 mL | |
| 50 mM | 0.0675 mL | 0.3375 mL | 0.6749 mL | 1.6873 mL | |
| 60 mM | 0.0562 mL | 0.2812 mL | 0.5624 mL | 1.4060 mL | |
| 80 mM | 0.0422 mL | 0.2109 mL | 0.4218 mL | 1.0545 mL | |
| 100 mM | 0.0337 mL | 0.1687 mL | 0.3375 mL | 0.8436 mL |
Propargyl-PEG4-sulfonic acid Related Classifications
HY-140047 Related Classifications
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