Proteasome-activating peptide 1 TFA
Based on 3 publication(s) in Google Scholar
Proteasome-activating peptide 1 TFA is a peptide and a potent proteasome activator. Proteasome-activating peptide 1 TFA increases the chymotrypsin-like proteasomal catalytic activity and, consequently, proteolytic rates both in vitro and in culture. Proteasome-activating peptide 1 TFA prevents protein aggregation in a cellular model of amyotrophic lateral sclerosis.
For research use only. We do not sell to patients.
- Purity: 98.13%
- Formula: C65H117F3N22O15S4
- Molecular Weight:1632.02
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Proteasome-activating peptide 1 TFA
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Biological Activity
Proteasome-activating peptide 1 (TFA) (0-100 μM, 2 h) increases ChT-L catalytic activity of the 20S proteasome in a dose-dependent manner[1].
Proteasome-activating peptide 1 (TFA) (50 μM, 24 h) induces the degradation of SOD1, promotes a decrease of oxidized proteins[1].
Proteasome-activating peptide 1 (TFA) (0-100 μM) protects fibroblast and SH-SY5Y cells from oxidative stress[1].
Proteasome-activating peptide 1 (TFA) only affects the free 20S proteasomal pool[1].
Proteasome-activating peptide 1 (TFA) promotes proteasomal gate opening[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human neuroblastoma (SH-SY5Y) and fibroblast cells[1]
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Concentration:0, 50, 100 μM (in DMEM without fetal bovine serum followed by the addition of H2O2 (500 or 750 μM) or water (0.4%))
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Incubation Time:30 min or 2 h
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Result:Promoted long-term proteasomal activation through interaction with the 20S core particle, increased ChT-L activity of the 20S proteasome in a dose-dependent manner, and did not reduce cell fibroblast viability.
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Cell Line:SH-SY5YG93A cells[1]
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Concentration:50 μM
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Incubation Time:24 h
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Result:Increased the degradation of soluble SOD1, prevented the formation of SOD1-insoluble aggregates, and decreased the oxidized proteins in the total intracellular content.
Chemical Information
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Appearance Solid
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Molecular Weight 1632.02
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Formula C65H117F3N22O15S4
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Color White to off-white
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Sequence Shortening
IPRCRKMPGVKMC-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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ACS Nano
Trehalose Acts as a Mediator: Imbalance in Brain Proteostasis Induced by Polystyrene Nanoplastics via Gut Microbiota Dysbiosis during Early Life. [Abstract]2025 May 27;19(20):19233-19254. PMID: 40359452 -
Cell Signal
USP12 regulates ER stress-associated osteogenesis in human periodontal ligament cells under tension stress. [Abstract]2024 Feb:114:111015. PMID: 38113977 -
Biomed Pharmacother
Proteasome-activating peptide 1 attenuates cardiac ischaemia/reperfusion-induced ferroptosis through the β5i-p53-SLC7A11 axis. [Abstract]2025 Aug:189:118296. PMID: 40580875
Solvent & Solubility
DMSO : 100 mg/mL (61.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Dal Vechio FH, et al. Peptides that activate the 20S proteasome by gate opening increased oxidized protein removal and reduced protein aggregation. Free Radic Biol Med. 2014;67:304-313. [Content Brief]
[2]. Dal Vechio FH, Cerqueira F, Augusto O, Lopes R, Demasi M. Peptides that activate the 20S proteasome by gate opening increased oxidized protein removal and reduced protein aggregation. Free Radic Biol Med. 2014 Feb;67:304-13. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.6127 mL | 3.0637 mL | 6.1274 mL | 15.3184 mL |
| 5 mM | 0.1225 mL | 0.6127 mL | 1.2255 mL | 3.0637 mL | |
| 10 mM | 0.0613 mL | 0.3064 mL | 0.6127 mL | 1.5318 mL | |
| 15 mM | 0.0408 mL | 0.2042 mL | 0.4085 mL | 1.0212 mL | |
| 20 mM | 0.0306 mL | 0.1532 mL | 0.3064 mL | 0.7659 mL | |
| 25 mM | 0.0245 mL | 0.1225 mL | 0.2451 mL | 0.6127 mL | |
| 30 mM | 0.0204 mL | 0.1021 mL | 0.2042 mL | 0.5106 mL | |
| 40 mM | 0.0153 mL | 0.0766 mL | 0.1532 mL | 0.3830 mL | |
| 50 mM | 0.0123 mL | 0.0613 mL | 0.1225 mL | 0.3064 mL | |
| 60 mM | 0.0102 mL | 0.0511 mL | 0.1021 mL | 0.2553 mL |
Proteasome-activating peptide 1 TFA Related Classifications
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