Polybrominated diphenyl ethers from a sponge of the Dysidea genus that inhibit Tie2 kinase

  • Bioorg Med Chem. 2005 Feb 1;13(3):657-9. doi: 10.1016/j.bmc.2004.10.061.
Ya-ming Xu  1 ,  Randall K Johnson ,  Sidney M Hecht
Affiliations
  • 1. Department of Chemistry, University of Virginia, Charlottesville, VA 22901, USA.
PMID: 15653332 DOI: 10.1016/j.bmc.2004.10.061
Abstract

Tie2 kinase, an enzyme that supports angiogenesis essential for tumor growth and survival, was selected as a target in a search for naturally occurring inhibitors of potential utility for antitumor therapy. Two polybrominated diphenyl ethers, 3,5-dibromo-2-(2',4'-dibromophenoxy)phenol (1) and 4,6-dibromo-2-(2',4'-dibromophenoxy)phenol (2) were isolated from an extract prepared from Dysidea sp. after bioassay-guided fractionation.

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