6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether
6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether is a selective inhibitor of Tie2 kinase, with an IC50 value of 2.1 μM. 6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether interacts with the ATP binding site of Tie2 kinase, inhibiting kinase activity and subsequently blocking tumor angiogenesis. 6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether can be isolated from sponges of the genus Dysidea.
For research use only. We do not sell to patients.
- CAS No.: 79755-43-4
- Formula: C12H6Br4O2
- Molecular Weight:501.79
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Tie2 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BSC-1 | IC50 |
7 μg/mL
Compound: 9
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Cytotoxicity against African green monkey BSC1 cells assessed as decrease in cell viability after 24 hrs by MTT assay
Cytotoxicity against African green monkey BSC1 cells assessed as decrease in cell viability after 24 hrs by MTT assay
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[PMID: 27399938] |
Chemical Information
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CAS No. 79755-43-4
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Molecular Weight 501.79
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Formula C12H6Br4O2
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SMILES
OC1=CC(Br)=CC(Br)=C1OC2=CC=C(Br)C=C2Br
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Structure Classification
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Initial Source
Dysidea sp.
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether Related Classifications
HY-N17788 Related Classifications
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