2. Protein Tyrosine Kinase/RTK
  3. Tie
  4. 6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether

6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether is a selective inhibitor of Tie2 kinase, with an IC50 value of 2.1 μM. 6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether interacts with the ATP binding site of Tie2 kinase, inhibiting kinase activity and subsequently blocking tumor angiogenesis. 6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether can be isolated from sponges of the genus Dysidea.

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6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether

6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether Chemical Structure

CAS No. : 79755-43-4

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Other Forms of 6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether:

6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether Related Antibodies

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Description

6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether is a selective inhibitor of Tie2 kinase, with an IC50 value of 2.1 μM. 6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether interacts with the ATP binding site of Tie2 kinase, inhibiting kinase activity and subsequently blocking tumor angiogenesis. 6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether can be isolated from sponges of the genus Dysidea[1].

IC50 & Target

Tie2

 

Cellular Effect
Cell Line Type Value Description References
BSC-1 IC50
7 μg/mL
Compound: 9
Cytotoxicity against African green monkey BSC1 cells assessed as decrease in cell viability after 24 hrs by MTT assay
Cytotoxicity against African green monkey BSC1 cells assessed as decrease in cell viability after 24 hrs by MTT assay
[PMID: 27399938]
Molecular Weight

501.79

Formula

C12H6Br4O2
CAS No.
SMILES

OC1=CC(Br)=CC(Br)=C1OC2=CC=C(Br)C=C2Br
Structure Classification
Initial Source

Dysidea sp.
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether79755-43-4TieAngiopoietin receptorInhibitorinhibitorinhibit

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6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether
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