79755-43-4
79755-43-4
Chemical Structure
6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether
- CAS No.: 79755-43-4
- Formula:C12H6Br4O2
- Molecular Weight:501.79
InChIKey: SNCQITRZEBFIRW-UHFFFAOYSA-N
SMILES: OC1=CC(Br)=CC(Br)=C1OC2=CC=C(Br)C=C2Br
Biological Activity: 6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether is a selective inhibitor of Tie2 kinase, with an IC50 value of 2.1 μM. 6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether interacts with the ATP binding site of Tie2 kinase, inhibiting kinase activity and subsequently blocking tumor angiogenesis. 6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether can be isolated from sponges of the genus Dysidea[1].
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6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether | 6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether is a selective inhibitor of Tie2 kinase, with an IC50 value of 2.1 μM. 6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether interacts with the ATP binding site of Tie2 kinase, inhibiting kinase activity and subsequently blocking tumor angiogenesis. 6-Hydroxy-2,2′,4,4′-tetrabromodiphenyl ether can be isolated from sponges of the genus Dysidea. | |||||||||||||||||||||
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2,2′,4,4′-Tetrabromo-6-hydroxydiphenyl ether-13C12 | 2,2′,4,4′-Tetrabromo-6-hydroxydiphenyl ether-13C12 is 13C labeled 2,2′,4,4′-Tetrabromo-6-hydroxydiphenyl ether. | |||||||||||||||||||||
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References
