CD1-Restricted T Cells in Inflammatory Skin Diseases

  • J Invest Dermatol. 2022 Mar;142(3 Pt B):768-773. doi: 10.1016/j.jid.2021.03.033.
Samantha Genardi  1 ,  Eva Morgun  1 ,  Chyung-Ru Wang  2
Affiliations
  • 1. Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
  • 2. Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA. Electronic address: [email protected].
PMID: 34130802 DOI: 10.1016/j.jid.2021.03.033
Abstract

Autoimmunity results from the breaking of immune tolerance, leading to inflammation and pathology. Although well studied in the conventional T-cell field, the role of nonconventional T cells in autoimmunity is less understood. CD1-restricted T cells recognize lipid antigens rather than peptide antigens and have been implicated in various autoimmune skin conditions, including psoriasis and atopic dermatitis. In this review, we will discuss the self-lipids that CD1-restricted T cells recognize and how these T cells become aberrantly regulated in pathogenic skin conditions.