Biological effects of acetomycin. I. Activity against tumor cells in vitro and in vivo

  • J Antibiot (Tokyo). 1987 Jan;40(1):73-6. doi: 10.7164/antibiotics.40.73.
S W Mamber ,  J D Mitulski ,  K L Hamelehle ,  J C French ,  G C Hokanson ,  J L Shillis ,  W R Leopold ,  D D Von Hoff ,  J B Tunac
PMID: 3558118 DOI: 10.7164/antibiotics.40.73
Abstract

The Antibiotic acetomycin was active in vitro against HCT-8 human colon adenocarcinoma cells (IC50, 1.5 microgram/ml) and L1210 murine leukemia cells (IC50, 2.2 micrograms/ml). Acetomycin also had marked activity in the human tumor stem cell assay, with a 33% overall response rate (less than or equal to 30% survival) against 49 primary tumors. However, acetomycin was inactive in four in vivo tumor assay systems (L1210 and P388 leukemias, B16 melanoma and the MX-1 mammary xenograft system). This lack of in vivo activity may result from metabolic inactivation of acetomycin.

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