2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Pumafentrine

Pumafentrine is an orally active, potent dual PDE3/PDE4 inhibitor. Pumafentrine dose-dependently ameliorates the clinical score and colonic TNFα production in murine Dextran sulphate sodium (DSS; HY-116282C)-induced colitis in a preventive setting.

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Pumafentrine

Pumafentrine Estructura química

No. CAS : 207993-12-2

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10 mg Obtener un presupuesto 2 - 3 weeks 1 - 2 weeks 3 - 4 weeks 2 - 3 weeks
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Pumafentrine Related Antibodies

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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Descripciòn

Pumafentrine is an orally active, potent dual PDE3/PDE4 inhibitor. Pumafentrine dose-dependently ameliorates the clinical score and colonic TNFα production in murine Dextran sulphate sodium (DSS; HY-116282C)-induced colitis in a preventive setting[1].

IC50 & Target[1]

PDE3

 

PDE4

 

Peso molecular

477.64

Fòrmula

C29H39N3O3
No. CAS
SMILES

COC1=C(OCC)C=C([C@@]2([H])[C@@](CCN(C2)C)([H])N=C3C4=CC=C(C=C4)C(N(C(C)C)C(C)C)=O)C3=C1
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Room temperature in continental US; may vary elsewhere.
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Pumafentrine Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pumafentrine207993-12-2Phosphodiesterase (PDE)OrallyDSScolitisInhibitorinhibitorinhibit

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HY-114766
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