Pyridine-3-sulfonyl chloride
Based on 1 Customer Validation
Pyridine-3-sulfonyl chloride is a sulfonyl chlorination derivatization reagent for steroidal estrogens. Pyridine-3-sulfonyl chloride reacts with estrogens to form pyridine-3-sulfonyl derivatives, which generate abundant analyte-specific fragment ions upon collision-induced dissociation. Pyridine-3-sulfonyl chloride facilitates quantitative LC-ESI-MS/MS analysis of estrogens in serum and water matrices.
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- Pureza : 99.98%
- No. CAS: 16133-25-8
- Fòrmula: C5H4ClNO2S
- Peso molecular:177.61
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Almacenamiento:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Descripciòn
In Vitro
Pyridine-3-sulfonyl chloride (1.0 mg/mL; 15 min at 60 °C) enhances ionization of steroidal estrogens for LC-ESI-MS/MS, produces analyte-specific fragment ions useful for structural identification, and enables quantitative analysis of 17β-estradiol in charcoal-stripped fetal bovine serum with a lower limit of quantitation of 10 pg/mL[1].
Pyridine-3-sulfonyl chloride (1 mg/mL) derivatizes E1, E2, E3, and EE2 in aqueous matrices with high efficiency, generating specific, high-intensity product ions that enable sensitive and selective UHPLC-ESI-MS/MS quantification, with limits of quantification ranging from 0.098 ng/L (EE2) to 2.73 ng/L (E3) in surface water using the optimized method[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 16133-25-8
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Appearance Solid-Liquid Mixture
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Peso molecular 177.61
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Fòrmula C5H4ClNO2S
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Color Colorless to light yellow
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SMILES
O=S(C1=CC=CN=C1)(Cl)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvente y solubilidad
In Vitro:
DMSO : 25 mg/mL (140.76 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (290 KB)
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SDS (476 KB)
- English - EN (476 KB)
- Français - FR (476 KB)
- Deutsch - DE (476 KB)
- Norwegian - NO (476 KB)
- Español - ES (476 KB)
- Swedish - SV (476 KB)
- Italian - IT (476 KB)
- Korean - KR (476 KB)
- Portuguese - PT (476 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.6303 mL | 28.1516 mL | 56.3031 mL | 140.7578 mL |
| 5 mM | 1.1261 mL | 5.6303 mL | 11.2606 mL | 28.1516 mL | |
| 10 mM | 0.5630 mL | 2.8152 mL | 5.6303 mL | 14.0758 mL | |
| 15 mM | 0.3754 mL | 1.8768 mL | 3.7535 mL | 9.3839 mL | |
| 20 mM | 0.2815 mL | 1.4076 mL | 2.8152 mL | 7.0379 mL | |
| 25 mM | 0.2252 mL | 1.1261 mL | 2.2521 mL | 5.6303 mL | |
| 30 mM | 0.1877 mL | 0.9384 mL | 1.8768 mL | 4.6919 mL | |
| 40 mM | 0.1408 mL | 0.7038 mL | 1.4076 mL | 3.5189 mL | |
| 50 mM | 0.1126 mL | 0.5630 mL | 1.1261 mL | 2.8152 mL | |
| 60 mM | 0.0938 mL | 0.4692 mL | 0.9384 mL | 2.3460 mL | |
| 80 mM | 0.0704 mL | 0.3519 mL | 0.7038 mL | 1.7595 mL | |
| 100 mM | 0.0563 mL | 0.2815 mL | 0.5630 mL | 1.4076 mL |
Pyridine-3-sulfonyl chloride Related Classifications
HY-32876 Related Classifications
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