2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. QTX125

QTX125 is a potent and highly selective HDAC6 inhibitor. QTX125 exhibits excellent selectivity over other HDACs. QTX125 has antitumor effects.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (QTX125 TFA) usually boasts enhanced water solubility and stability.

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QTX125

QTX125 Estructura química

No. CAS : 1279698-31-5

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QTX125 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE QTX125

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Descripciòn

QTX125 is a potent and highly selective HDAC6 inhibitor. QTX125 exhibits excellent selectivity over other HDACs. QTX125 has antitumor effects[1].

IC50 & Target[1]

HDAC6

 

In Vitro

QTX125 (25-500 nM; 24-48 hours) treatment induces the subsequent apoptosis demonstrated by annexin V/propidium iodide double staining and the cleavage of caspase-9, caspase-8, caspase-3, and PARP[1].
In MCL cell lines MINO, REC-1, IRM-2 and HBL-2 cells, QTX125 (10 nM, 10 μM, 100 μM) induces dose-dependent hyperacetylation of α-tubulin[1].
QTX125 has the strongest growth-inhibitory effect in Burkitt cell lymphoma, follicular lymphoma, and mantle cell lymphoma (MCL)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

QTX125 Related Antibodies

Apoptosis Analysis[1]

Cell Line: MINO, REC-1, IRM-2 and HBL-2 cells
Concentration: 25 nM, 50 nM, 100 nM, 500 nM
Incubation Time: 24 hours, 48 hours
Result: Inhibited annexin V/propidium iodide double staining.

Western Blot Analysis[1]

Cell Line: MINO, REC-1, IRM-2 and HBL-2 cells
Concentration: 25 nM, 50 nM, 100 nM, 500 nM
Incubation Time: 24 hours
Result: Inhibited the cleavage of caspase-9, caspase-8, caspase-3, and PARP.
In Vivo

QTX125 (60 mg/kg; i.p.; daily dosing for 5 days; for 4 weeks) treatment inhibits tumor growth in REC-1 or MINO cells xenografted in nude mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice bearing REC-1 or MINO cells[1]
Dosage: 60 mg/kg
Administration: Intraperitoneal administration; daily dosing for 5 days; for 4 weeks
Result: Inhibited tumor growth in REC-1 or MINO cells xenografted in nude mice.
Peso molecular

417.41

Fòrmula

C23H19N3O5
No. CAS
SMILES

O=C(C1=C(C2=COC=C2)C=C(C3=CC=C(O)C=C3)N1)NCC4=CC=C(C(NO)=O)C=C4
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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QTX125 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

QTX1251279698-31-5QTX 125QTX-125HDACApoptosisHistone deacetylasesα-tubulinHDAC6antitumorcaspase-9caspase-8caspase-3PARPInhibitorinhibitorinhibit

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QTX125
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HY-120448
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