(±)-Boc-α-phosphonoglycine trimethyl ester

Name: (±)-Boc-α-phosphonoglycine trimethyl ester
Brand: MedChemExpress
SKU: HY-W008206
Rating: 4.5 (1 reviews)

Cat. No.: HY-W008206 Purity: 99.20%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

(±)-Boc-α-phosphonoglycine trimethyl ester serves as a glycine equivalent and glycine donor in organic synthesis.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

(±)-Boc-α-phosphonoglycine trimethyl ester 화학구조

CAS No. : 89524-98-1

사이즈	재고	수량

무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
무료 샘플 (0.1 - 0.2 mg)	지금 신청하기
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
5 g	해외재고보유	Estimated Time of Arrival: December 31
10 g	해외재고보유	Estimated Time of Arrival: December 31
25 g	해외재고보유	Estimated Time of Arrival: December 31
50 g	해외재고보유	Estimated Time of Arrival: December 31
100 g	해외재고보유	Estimated Time of Arrival: December 31
500 g	해외재고보유	Estimated Time of Arrival: December 31
> 100 g	견적 받기

or 대량구매 문의

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This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 publication(s) in Google Scholar

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

(±)-Boc-α-phosphonoglycine trimethyl ester serves as a glycine equivalent and glycine donor in organic synthesis^[1].

In Vitro

(±)-Boc-α-phosphonoglycine trimethyl ester has strong α-proton acidity, and its reaction byproducts have good water solubility and are easy to purify. The target 5,6- and 5,8-dimethoxy-substituted ester products are efficiently obtained via four mild reactions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

297.24

화학식

C₁₀H₂₀NO₇P

CAS No.

89524-98-1

Appearance

Solid

Color

White to off-white

SMILES

O=C(C(NC(OC(C)(C)C)=O)P(OC)(OC)=O)OC

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

용액&용해도

In Vitro:

DMSO : 100 mg/mL (336.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3643 mL	16.8214 mL	33.6428 mL
5 mM	0.6729 mL	3.3643 mL	6.7286 mL
10 mM	0.3364 mL	1.6821 mL	3.3643 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (16.82 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (16.82 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

순도&문서

Purity: 99.20%

Select Batch:

Data Sheet (290 KB) SDS (480 KB)

COA (251 KB) HNMR (246 KB) RP-HPLC (250 KB) MS (70 KB)

Handling Instructions (2659 KB)

References

[1]. Al-Horani RA, et al. Electronically Rich N-Substituted Tetrahydroisoquinoline 3-Carboxylic Acid Esters: Concise Synthesis and Conformational Studies. Tetrahedron. 2012 Feb 25;68(8):2027-2040. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3643 mL	16.8214 mL	33.6428 mL	84.1071 mL
	5 mM	0.6729 mL	3.3643 mL	6.7286 mL	16.8214 mL
	10 mM	0.3364 mL	1.6821 mL	3.3643 mL	8.4107 mL
	15 mM	0.2243 mL	1.1214 mL	2.2429 mL	5.6071 mL
	20 mM	0.1682 mL	0.8411 mL	1.6821 mL	4.2054 mL
	25 mM	0.1346 mL	0.6729 mL	1.3457 mL	3.3643 mL
	30 mM	0.1121 mL	0.5607 mL	1.1214 mL	2.8036 mL
	40 mM	0.0841 mL	0.4205 mL	0.8411 mL	2.1027 mL
	50 mM	0.0673 mL	0.3364 mL	0.6729 mL	1.6821 mL
	60 mM	0.0561 mL	0.2804 mL	0.5607 mL	1.4018 mL
	80 mM	0.0421 mL	0.2103 mL	0.4205 mL	1.0513 mL
	100 mM	0.0336 mL	0.1682 mL	0.3364 mL	0.8411 mL