(±)-Boc-α-phosphonoglycine trimethyl ester
Based on 1 Customer Validation
(±)-Boc-α-phosphonoglycine trimethyl ester serves as a glycine equivalent and glycine donor in organic synthesis.
For research use only. We do not sell to patients.
- Purity: 99.20%
- CAS No.: 89524-98-1
- Formula: C10H20NO7P
- Molecular Weight:297.24
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Storage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-33291
N-Benzyloxycarbonyl-2-phosphonoglycine trimethyl ester
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HY-108309
Medronic acid
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HY-107859
Tris(2-chloroethyl) phosphate
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HY-108309R
Medronic acid (Standard)
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HY-Y0677
Triethyl phosphonoacetate
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HY-Y1322
Triphenyl phosphate
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HY-W017894
TPO-L
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HY-W002322
tert-Butyl Diethylphosphonoacetate
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HY-W008151
Diphenyl Phosphate
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HY-76459
Diethyl (cyanomethyl)phosphonate
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HY-W016414
Triethyl phosphate
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HY-101417
Diethyl phosphate
Biological Activity
(±)-Boc-α-phosphonoglycine trimethyl ester has strong α-proton acidity, and its reaction byproducts have good water solubility and are easy to purify. The target 5,6- and 5,8-dimethoxy-substituted ester products are efficiently obtained via four mild reactions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 89524-98-1
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Appearance Solid
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Molecular Weight 297.24
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Formula C10H20NO7P
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Color White to off-white
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SMILES
O=C(C(NC(OC(C)(C)C)=O)P(OC)(OC)=O)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL (336.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (16.82 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (274 KB)
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SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.3643 mL | 16.8214 mL | 33.6428 mL | 84.1071 mL |
| 5 mM | 0.6729 mL | 3.3643 mL | 6.7286 mL | 16.8214 mL | |
| 10 mM | 0.3364 mL | 1.6821 mL | 3.3643 mL | 8.4107 mL | |
| 15 mM | 0.2243 mL | 1.1214 mL | 2.2429 mL | 5.6071 mL | |
| 20 mM | 0.1682 mL | 0.8411 mL | 1.6821 mL | 4.2054 mL | |
| 25 mM | 0.1346 mL | 0.6729 mL | 1.3457 mL | 3.3643 mL | |
| 30 mM | 0.1121 mL | 0.5607 mL | 1.1214 mL | 2.8036 mL | |
| 40 mM | 0.0841 mL | 0.4205 mL | 0.8411 mL | 2.1027 mL | |
| 50 mM | 0.0673 mL | 0.3364 mL | 0.6729 mL | 1.6821 mL | |
| 60 mM | 0.0561 mL | 0.2804 mL | 0.5607 mL | 1.4018 mL | |
| 80 mM | 0.0421 mL | 0.2103 mL | 0.4205 mL | 1.0513 mL | |
| 100 mM | 0.0336 mL | 0.1682 mL | 0.3364 mL | 0.8411 mL |
(±)-Boc-α-phosphonoglycine trimethyl ester Related Classifications
HY-W008206 Related Classifications
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