2. Others Metabolic Enzyme/Protease
  3. Environmental Pollutants Endogenous Metabolite
  4. Triethyl phosphate

Triethyl phosphate is a versatile phosphate ester compound. Triethyl phosphate induces rapid and short-acting anesthesia, and exhibits hypotensive, smooth muscle relaxant, and cardiac inhibitory effects. Triethyl phosphate also modulates cholinergic toxicity; its anesthetic effect shows sex- and age-dependency in rodents, and it interacts with SKF 525-A (HY-B1311) to alter the duration of anesthesia.

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Triethyl phosphate

Triethyl phosphate Chemical Structure

CAS No. : 78-40-0

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Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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Triethyl phosphate Related Antibodies

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Description

Triethyl phosphate is a versatile phosphate ester compound. Triethyl phosphate induces rapid and short-acting anesthesia, and exhibits hypotensive, smooth muscle relaxant, and cardiac inhibitory effects. Triethyl phosphate also modulates cholinergic toxicity; its anesthetic effect shows sex- and age-dependency in rodents, and it interacts with SKF 525-A (HY-B1311) to alter the duration of anesthesia[1][2].

In Vivo

Triethyl phosphate (333-500 mg/kg; i.p.) induces anesthesia in adult Holtzman rats, with an ED50 of 333 mg/kg in female rats and 412 mg/kg in male rats; it exerts minimal effects on brain cholinesterase activity at a dose of 500 mg/kg[2].
Triethyl phosphate (437-500 mg/kg; i.p.) exhibits weaker anesthetic potency in weanling Holtzman rats than in adult rats, with an ED50 value of 437 mg/kg in female rats and 495 mg/kg in male rats, and the duration of anesthesia is shorter at 500 mg/kg[2].
Triethyl phosphate (600-690 mg/kg; i.p.) induces anesthesia in adult male Swiss Webster mice, with an ED50 of 600 mg/kg, and triggers an anesthetic response with rapid onset, short duration, and mild persistent ataxia[2].
The duration of anesthesia induced by triethyl phosphate (500 mg/kg; i.p.) in adult female Holtzman rats is not affected by pre-administration of phenobarbital or SKF 525-A (HY-B1311)[2].
The duration of anesthesia induced by triethyl phosphate (690 mg/kg; i.p.) in adult male Swiss Webster mice is significantly shortened by phenobarbital pretreatment, while it is significantly prolonged by SKF 525-A pretreatment[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss Webster mice (adult, male)[2]
Dosage: 600 mg/kg (ED50); 650 mg/kg; 690 mg/kg
Administration: i.p.
Result: Determined ED50 dose for loss of righting reflex as 600 mg/kg.
Observed onset of narcosis within 5 minutes after injection, with duration less than 2 hours and little persistent ataxia.
Animal Model: Holtzman rats (adult, female)[2]
Dosage: 500 mg/kg
Administration: i.p.
Result: Recorded mean duration of loss of righting reflex as 31.8 minutes in control rats, 42.1 minutes in phenobarbital-pretreated rats, 34.5 minutes in SKF 525-A (2-hour pretreatment) rats, and 40.6 minutes in SKF 525-A (1-hour pretreatment) rats; none of these differences were statistically significant.
Molecular Weight

182.15

Formula

C6H15O4P
CAS No.
Appearance

Liquid (Density: 1.072 g/cm3)

Color

Colorless to light yellow

SMILES

CCOP(OCC)(OCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 200 mg/mL (1098.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4900 mL 27.4499 mL 54.8998 mL
5 mM 1.0980 mL 5.4900 mL 10.9800 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation

Purity: 99.95%

SDS (393 KB)

COA (246 KB) HNMR (116 KB) GC (178 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.4900 mL 27.4499 mL 54.8998 mL 137.2495 mL
5 mM 1.0980 mL 5.4900 mL 10.9800 mL 27.4499 mL
10 mM 0.5490 mL 2.7450 mL 5.4900 mL 13.7250 mL
15 mM 0.3660 mL 1.8300 mL 3.6600 mL 9.1500 mL
20 mM 0.2745 mL 1.3725 mL 2.7450 mL 6.8625 mL
25 mM 0.2196 mL 1.0980 mL 2.1960 mL 5.4900 mL
30 mM 0.1830 mL 0.9150 mL 1.8300 mL 4.5750 mL
40 mM 0.1372 mL 0.6862 mL 1.3725 mL 3.4312 mL
50 mM 0.1098 mL 0.5490 mL 1.0980 mL 2.7450 mL
60 mM 0.0915 mL 0.4575 mL 0.9150 mL 2.2875 mL
80 mM 0.0686 mL 0.3431 mL 0.6862 mL 1.7156 mL
100 mM 0.0549 mL 0.2745 mL 0.5490 mL 1.3725 mL
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Triethyl phosphate Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Triethyl78-40-0Environmental PollutantsEndogenous MetaboliteEnvironmental Contaminantsrodentssolar celliodide vacanciessmooth muscleparaoxon-induced cholinergic toxicitycardiac functionCH 3 NH 3 PbI 3 perovskiteHoltzman ratsSwiss Webster micePb 2+ ions
Inhibitorinhibitorinhibit

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