ADH1B Protein, Human (His-SUMO)
Based on 1 Customer Validation
ADH1B Protein, Human (His-SUMO) is an enzyme encoded by the ADH1B gene and is involved in the main ethanol metabolism pathway.
- Species: Human
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- References
- Help & FAQs
Biological Activity
Description
ADH1B Protein, Human (His-SUMO) is an enzyme encoded by the ADH1B gene and is involved in the main ethanol metabolism pathway.
Background
The ADH1B (Alcohol Dehydrogenase 1B (class I), β Polypeptide) gene and its best-known functional alleles, Arg48His (rs1229984, ADH1B*2) and Arg370Cys (rs2066702, ADH1B*3), have been investigated in relation to many phenotypic traits; most frequently including alcohol metabolism and alcohol drinking behaviors, but also human evolution, liver function, cancer, and, recently, the comprehensive human phenome. ADH1B is reported to be involved in the metabolic pathways of many compounds besides ethanol, including fatty acids, acetone, epinephrine, glucose, retinol, tyrosine, tryptophan, ifosfamide, cyclophosphamide, abacavir, and celecoxib; and notably, neurotransmitters serotonin and norepinephrine[1][2].
Verified Bioactivity
The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.
Technical Parameters
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Species Human
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Source E. coli
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Tag N-6*His;N-SUMO
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Accession
P00325 (S2-F375, H48R)
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Molecular Construction
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N-term
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6*His-SUMO
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ADH1B (S2-F375, H48R)
Accession # P00325 -
C-term
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Protein Length
Full Length
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Mutation
H48R
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Mutation Definition
Natural variant
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Synonyms
ADH1B; Alcohol Dehydrogenase 2 (Class I), Beta Polypeptide; Prev. ADH2; Aldehyde Reductase; All-Trans-Retinol Dehydrogenase [NAD(+)] ADH1B; ADH, Beta Subunit; Epididymis Secretory Protein Li 117; HEL-S-117; Alcohol Dehydrogenase Subunit Beta; Alcohol Dehy
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AA Sequence
STAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTVLTF
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Predicted Molecular Mass
55.7 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder
Lyophilized from a 0.22 μm filtered solution of PBS, 6% trehalose, pH 7.4.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (264 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Renato Polimanti, et al. ADH1B: From alcoholism, natural selection, and cancer to the human phenome. Am J Med Genet B Neuropsychiatr Genet. 2018 Mar;177(2):113-125. [Content Brief]
[2]. Liza D Morales, et al. Further evidence supporting a potential role for ADH1B in obesity. Sci Rep. 2021 Jan 21;11(1):1932. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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