AMCase/CHIA Protein, Mouse (HEK293, His)
AMCase/CHIA Protein, an enzyme, is a member of the chitinase family that hydrolyzes chitin, a component of the fungal cell wall. It plays a crucial role in the immune response against fungal infections. AMCase/CHIA Protein's potential as a therapeutic target lies in its ability to modulate the immune system and its involvement in allergic diseases and asthma. AMCase/CHIA Protein, Mouse (HEK293, His) is the recombinant mouse-derived AMCase/CHIA protein, expressed by HEK293 , with C-His labeled tag.
- Species: Mouse
- Source: HEK293
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
AMCase/CHIA Protein, an enzyme, is a member of the chitinase family that hydrolyzes chitin, a component of the fungal cell wall. It plays a crucial role in the immune response against fungal infections. AMCase/CHIA Protein's potential as a therapeutic target lies in its ability to modulate the immune system and its involvement in allergic diseases and asthma. AMCase/CHIA Protein, Mouse (HEK293, His) is the recombinant mouse-derived AMCase/CHIA protein, expressed by HEK293 , with C-His labeled tag.
Background
AMCase/CHIA Protein is an important enzyme involved in the degradation of chitin and chitotriose, which are essential components of the cell walls of fungi, nematodes, and other pathogens. This protein is believed to play a significant role in the defense against these pathogens, contributing to the body's immune response, particularly the T-helper cell type 2 (Th2) immune response. It is also involved in the response to interleukin-13 (IL-13) and the subsequent inflammation caused by IL-13. Additionally, AMCase/CHIA Protein stimulates the production of chemokines by pulmonary epithelial cells and protects lung epithelial cells from apoptosis, promoting the phosphorylation of AKT1. Its ability to function in the inflammatory response and protect cells against apoptosis is hindered by allosamidin, indicating that carbohydrate binding is crucial for its function. The presence of AMCase/CHIA Protein in saliva and gastric juice further suggests its role as a digestive enzyme.
Technical Parameters
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Species Mouse
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Source HEK293
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Tag C-8*His
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Accession
Q91XA9 (Y22-P473)
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Molecular Construction
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N-term
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CHIA (Y22-P473)
Accession # Q91XA9 -
8*His
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C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
CHIA; TSA1902; Chitinase Acidic; CHIT2; Acidic Mammalian Chitinase; Lung-Specific Protein TSA1902; AMCase; Chitinase, Acidic
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AA Sequence
YNLICYFTNWAQYRPGLGSFKPDDINPCLCTHLIYAFAGMQNNEITTIEWNDVTLYKAFNDLKNRNSKLKTLLAIGGWNFGTAPFTTMVSTSQNRQTFITSVIKFLRQYGFDGLDLDWEYPGSRGSPPQDKHLFTVLVKEMREAFEQEAIESNRPRLMVTAAVAGGISNIQAGYEIPELSKYLDFIHVMTYDLHGSWEGYTGENSPLYKYPTETGSNAYLNVDYVMNYWKNNGAPAEKLIVGFPEYGHTFILRNPSDNGIGAPTSGDGPAGPYTRQAGFWAYYEICTFLRSGATEVWDASQEVPYAYKANEWLGYDNIKSFSVKAQWLKQNNFGGAMIWAIDLDDFTGSFCDQGKFPLTSTLNKALGISTEGCTAPDVPSEPVTTPPGSGSGGGSSGGSSGGSGFCADKADGLYPVADDRNAFWQCINGITYQQHCQAGLVFDTSCNCCNWP
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Predicted Molecular Mass
51 kDa
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Molecular Weight
Approximately 53-60 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Purity
≥ 95%, as determined by Bis-Tris PAGE.
Product Properties
Solution
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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