1. Recombinant Proteins
  2. CD Antigens Receptor Proteins
  3. NK Cell CD Proteins Macrophage CD Proteins Monocyte CD Proteins Platelet CD Proteins Erythrocyte CD Proteins Dendritic Cell CD Proteins Endothelial cell CD Proteins Cell Adhesion Molecules (CAMs)
  4. ICAM-2/CD102 Immunoglobulin-like Cell Adhesion Molecules
  5. ICAM-2/CD102 Protein, Human (199a.a, HEK293, His)

ICAM-2/CD102 Protein, Human (199a.a, HEK293, His)

Cat. No.: HY-P7775
COA Handling Instructions

CD102 Protein, Human (HEK293, His) is a transmembrane glycoprotein of the immunoglobulin superfamily.

For research use only. We do not sell to patients.

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50 μg $195 In-stock
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Description

CD102 Protein, Human (HEK293, His) is a transmembrane glycoprotein of the immunoglobulin superfamily.

Background

ICAM-2 (CD102), like the structurally related ICAM-1 (CD54) and ICAM-3 (CD50) proteins is a known ligand for the ß2 family of leukocyte integrins. These include CD11a/CD18 (LFA-1), CD11b/CD18 (Mac-1), and the dendritic cell-specific, ICAM-grabbing non-integrin (DC-SIGN) protein. ICAM-2 harbours two immunoglobulin domains which are homologues to the first and second immunoglobulin domain of ICAM-1 without any known splice variants. ICAM-2 is uniformly present on all subsets of B lymphocyte lineage cells in bone marrow cell suspensions. High level constitutive expression on vascular endothial cells and less responsiveness than ICAM-1 to inflammatory stimuli are also characteristics of ICAM-2. Recombinant ICAM-2 can co-stimulate T cells in vitro. Although ICAM-2 mediates neutrophil transmigration, ICAM-2 appears capable of mediating CD31/PECAM-1-independent leukocyte transmigration. ICAM-2 may also regulate angiogenesis via several mechanisms including survival, cell migration, and Rac activation[1][2].

Species

Human

Source

HEK293

Tag

C-6*His

Accession

P13598 (K25-Q223)

Gene ID
Synonyms
rHuCD102, His; Intercellular Adhesion Molecule 2; ICAM-2; CD102; ICAM2
AA Sequence

KVFEVHVRPKKLAVEPKGSLEVNCSTTCNQPEVGGLETSLDKILLDEQAQWKHYLVSNISHDTVLQCHFTCSGKQESMNSNVSVYQPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQHHHHHH

Molecular Weight

Approximately 43 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Appearance

Lyophilized powder.

Formulation

Lyophilized after extensive dialysis against PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation
References
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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Product Name:
ICAM-2/CD102 Protein, Human (199a.a, HEK293, His)
Cat. No.:
HY-P7775
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