ICAM-2/CD102 Protein, Human (HEK293, His)
Based on 1 Customer Validation
ICAM-2/CD102 Protein, Human (HEK293, His) is a transmembrane glycoprotein of the immunoglobulin superfamily.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- References
- Help & FAQs
Biological Activity
ICAM-2/CD102 Protein, Human (HEK293, His) is a transmembrane glycoprotein of the immunoglobulin superfamily.
ICAM-2 (CD102), like the structurally related ICAM-1 (CD54) and ICAM-3 (CD50) proteins is a known ligand for the ß2 family of leukocyte integrins. These include CD11a/CD18 (LFA-1), CD11b/CD18 (Mac-1), and the dendritic cell-specific, ICAM-grabbing non-integrin (DC-SIGN) protein. ICAM-2 harbours two immunoglobulin domains which are homologues to the first and second immunoglobulin domain of ICAM-1 without any known splice variants. ICAM-2 is uniformly present on all subsets of B lymphocyte lineage cells in bone marrow cell suspensions. High level constitutive expression on vascular endothial cells and less responsiveness than ICAM-1 to inflammatory stimuli are also characteristics of ICAM-2. Recombinant ICAM-2 can co-stimulate T cells in vitro. Although ICAM-2 mediates neutrophil transmigration, ICAM-2 appears capable of mediating CD31/PECAM-1-independent leukocyte transmigration. ICAM-2 may also regulate angiogenesis via several mechanisms including survival, cell migration, and Rac activation[1][2].
Technical Parameters
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Species Human
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Source HEK293
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Tag C-6*His
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Accession
P13598 (K25-Q223)
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Protein Length
Extracellular Domain
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Synonyms
ICAM2; Intercellular Adhesion Molecule 2, Isoform CRA_a; Intercellular Adhesion Molecule 2; CD102 Antigen; CD102; ICAM2 Protein; ICAM-2
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AA Sequence
KVFEVHVRPKKLAVEPKGSLEVNCSTTCNQPEVGGLETSLDKILLDEQAQWKHYLVSNISHDTVLQCHFTCSGKQESMNSNVSVYQPPRQVILTLQPTLVAVGKSFTIECRVPTVEPLDSLTLFLFRGNETLHYETFGKAAPAPQEATATFNSTADREDGHRNFSCLAVLDLMSRGGNIFHKHSAPKMLEIYEPVSDSQ
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Predicted Molecular Mass
23.1 kDa
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Molecular Weight
Approximately 40-60 kDa, based on SDS-PAGE under reducing conditions.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
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Data Sheet (263 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Yoshio Yamashita, et al. Participation of intercellular adhesion molecule-2 (CD102) in B lymphopoiesis. Immunol Lett. 2008 Oct 30;120(1-2):79-86. [Content Brief]
[2]. Ruth Lyck, et al. The physiological roles of ICAM-1 and ICAM-2 in neutrophil migration into tissues. Curr Opin Hematol. 2015 Jan;22(1):53-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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