ICAM2 - intercellular adhesion molecule 2 Gene

Also Known as CD102

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3384

About ICAM2

Cytogenetic location: 17q23.3 Genomic coordinates (GRCh38): 17:64,002,595-64,020,633 (from NCBI)

This gene has 16 transcripts (splice variants), 105 orthologues and 4 paralogues. Broad expression in spleen (RPKM 62.3), placenta (RPKM 26.4) and 17 other tissues.

Summary

The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and Other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

ICAM2 Products (5)

mRNA Protein Name
NM_000873.4 NP_000864.2 intercellular adhesion molecule 2 precursor
NM_001099786.2 NP_001093256.1 intercellular adhesion molecule 2 precursor
NM_001099787.2 NP_001093257.1 intercellular adhesion molecule 2 precursor
NM_001099788.2 NP_001093258.1 intercellular adhesion molecule 2 precursor
NM_001099789.2 NP_001093259.1 intercellular adhesion molecule 2 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables integrin binding IPI
IPI: Inferred from physical interaction
1448173 GOA
Cellular Component GO Annotation Evidence References Source
located in cleavage furrow IDA
IDA: Inferred from direct assay
19799413 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ICAM2 Protein Structure

ICAM_N

ICAM_N: Intercellular adhesion molecule (ICAM), N-terminal domain (24 - 114)

  • 0
  • 100
  • 200
  • 275 a.a.
Protein Preferred Names Protein Names

intercellular adhesion molecule 2

  • ICAM-2

Recombinant ICAM2 Proteins

Cat. No. Product Name Accession Purity
HY-P7775 ICAM-2/CD102 Protein, Human (HEK293, His) P13598 (K25-Q223) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73115 ICAM-2/CD102 Protein, Human (HEK293, His-Fc) Q6FHE2/NP_000864.2 (K25-Q223) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73116 ICAM-2/CD102 Protein, Human (HEK293, His, solution) Q6FHE2 (S22-Q223) ≥ 95%, as determined by reducing SDS-PAGE.

ICAM2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83262 ICAM2 Antibody (YA3007) WB, IHC-P, IP Human, Mouse
HY-P83262A ICAM2 Antibody (YA3007)(PBS only) WB, IHC-P, IP Human, Mouse
HY-P84084 CD102 Antibody (YA3781) IHC-P, FC, ELISA Human
HY-P84084A CD102 Antibody (YA3781)(PBS only) IHC-P, FC, ELISA Human

Related Diseases

Diseases Alias
Leukocyte Adhesion Deficiency, Type I

  • Leukocyte Adhesion Deficiency

  • Leukocyte Adhesion Deficiency 1

  • LAD1

  • Lad

  • Lymphocyte Function-Associated Antigen 1 Immunodeficiency

  • Leukocyte Adhesion Deficiency Type I

  • Leukocyte Adhesion Deficiency Type 1

  • Linear Iga Bullous Dermatosis

  • Linear Iga Dermatosis

  • Leukocyte-Adhesion Deficiency Syndrome

  • Lfa1 Immunodeficiency

  • Congenital Leukocyte Adherence Deficiency

  • Lad-I

  • Linear Iga Disease

  • Leukocyte Adhesion Deficiency Syndrome

  • Lad 1

  • Lfa 1 Immunodeficiency

  • Linear Immunoglobulin A Dermatosis

  • Leucocyte Adhesion Deficiency Type 1

  • Leukocyte Adhesion Molecule Deficiency Type 1
Colon Carcinoma In Situ

  • Carcinoma In Situ Of Colon

  • Stage 0 Colonic Carcinoma

  • Stage 0 Carcinoma Of Colon

  • Intraepithelial Neoplasia Of Colon, High Grade

  • Carcinoma In Situ Of Cecum

  • Carcinoma In Situ Of Hepatic Flexure

  • Carcinoma In Situ Of Ileocecal Valve

  • Carcinoma In Situ Of Hepatic Flexure Of Colon
Intestine Carcinoma In Situ
Polyarteritis Nodosa

  • Polyarteritis

  • Periarteritis Nodosa

  • Pan

  • Periarteritis

  • Kussmaul-Maier Disease

  • Panarteritis Nodosa

  • Kussmaul Disease

  • Pan - [Polyarteritis Nodosa]

  • Polyangiitis

  • Panangiitis

  • Arteritis Nodosa
Malaria

  • Malaria, Susceptibility To

  • Malaria, Resistance To

  • Malaria, Cerebral

  • Cerebral Malaria

  • Malaria, Severe, Susceptibility To

  • Malaria, Severe, Resistance To

  • Malaria, Cerebral, Susceptibility To

  • Induced Malaria

  • Malaria, Vivax, Protection Against

  • Malaria, Severe

  • Malaria, Cerebral, Reduced Risk Of

  • Malaria, Protection Against

  • Resistance To Malaria Due To G6pd Deficiency

  • Malaria Due To G6pd Deficiency

  • Malarial Encephalitis

  • CM

  • Malaria Cerebral

  • Susceptibility To Malaria

  • Acute Pernicious Fever

  • Aestivo-Autumnal Fever

  • Aestivo Autumnal Malaria

  • Chagres Fever

  • Continued Malaria Fever

  • Estivo-Autumnal Fever

  • Estivo-Autumnal Malaria

  • Estivo-Autumnal Malarial Fever

  • Falciparum Fever

  • Malignant Tertian Fever

  • Malignant Tertian Malaria

  • Pernicious Intermittent Fever

  • Pernicious Malaria

  • Quotidian Malaria

  • Subtertian Fever

  • Subtertian Malaria Fever

  • Subtertian Malignant Tertian Malaria

  • Tropical Malaria

  • Algid Malaria

  • Bilious Haemoglobinuric Fever

  • Black Water Fever

  • Blackwater Fever

  • Malarial Blackwater Fever

  • Severe Malarial Falciparum

  • West African Fever

  • Malarial Haematinuria

  • Haemoglobinuric Fever

  • Haemoglobinuric Malaria

  • Severe Plasmodium Falciparum Malaria

  • Malarial Haemoglobinuria

  • Malarial Haematuria

  • Falciparum Malaria [Malignant Tertian]

  • Malaria Tropica

  • Malarial Shock

  • Chagres Virus Disease

  • Malignant Malaria

  • Mtm - [Malignant Tertian Malaria]

  • Tm -[Malignant Tertian Malaria]

  • Panama Fever

  • St - [Subtertian Malaria]

  • Malarial Quotidian

  • Benign Tertian Malaria

  • Tertian Ague

  • Vivax Fever

  • Plasmodium Vivax Malaria Nos

  • Btm - [Benign Tertian Malaria]

  • Bt - [Benign Tertian Malaria]

  • Vivax Malaria

  • Benign Tertian Vivax Malaria

  • Tertian Malaria

  • Quartan Malaria

  • Quartan Ague

  • Quartan Fever

  • Plasmodium Malariae Malaria Nos

  • Quartan Malarial

  • Malaria By Plasmodium Malariae

  • Malariae Malaria

  • Ovale Tertian Malaria

  • Plasmodium Ovale Fever

  • Malaria Fever By Plasmodium Ovale

  • Ovale Malaria

  • Malaria By Plasmodium Ovale

  • Malarial Ovale

  • Marsh Fever

  • Remittent Congestive Fever

  • Coastal Fever

  • Remittent Gastric Fever

  • Miasmatic Fever

  • Congestive Remittent Fever

  • Intermittent Fever

  • Jungle Fever

  • Paludism

  • Cameroon Fever

  • Ague

  • Corsican Fever

  • Intermittent Bilious Fever

  • Disease Due To Plasmodiidae

  • Malarial Fever

  • Plasmodiosis

  • Remittent Fever

  • Roman Fever

  • Malaria Fever Nos

  • Malaria Nos

  • Paludal Fever

  • Clinically Diagnosed Malaria

  • Clinically Diagnosed Malaria Without Parasitological Confirmation

  • Congestive Fever

  • Malarial Cachexia

  • Marsh Cachexia

  • Paludal Cachexia

  • Recurrent Malaria

  • Remittent Malaria
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Immune Deficiency Disease

  • Immunodeficiency

  • Primary Immunodeficiency

  • Primary Immunodeficiency Disease

  • Immunologic Deficiency Syndromes

  • Hypoimmunity

  • Immune Deficiency Disorder

  • Immunodeficiency Syndrome

  • Immune Disorder

  • Primary Immune Deficiency Disorder

  • Immune System Diseases

  • Human Immunodeficiency Virus Infection

  • Hiv - [Human Immunodeficiency Virus Infection]

  • Hiv Positive Nos

  • Hiv Disease

  • Acquired Immune Deficiency Syndrome-Related Complex

  • Aids-Like Syndrome

  • Aids-Related Complex Nos

  • Arc - [Aids-Related Complex]

  • Immunodeficiency Due To Human Immunodeficiency Virus Infection

  • Unspecified Human Immunodeficiency Virus Disease

  • Hiv Disease Nos

  • Human Immunodeficiency Virus Positive Nos

  • Hiv Nos

  • Deficiency Of Complement Initial Pathway

  • Deficiency Of Complement Terminal Pathway

  • Cfdd - [Complement Factor D Deficiency]

  • Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency

  • Nonfamilial Hypogammaglobulinaemia

  • Common Variable Immune Deficiency

  • Nonfamilial Agammaglobulinaemia

  • Common Variable Agammaglobulinaemia

  • Agammaglobulinaemia Nos

  • Agammaglobulinaemia Antibody Deficiency Syndrome

  • Hypogammaglobulinaemia Antibody Deficiency Syndrome

  • Acquired Agammaglobulinaemia Nos

  • Hypogammaglobulinaemia Nos

  • Hyper Igm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06513 ICAM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19444 Icam2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25936 Icam2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992413 MOR102 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ICAM2 VGNC VGNC:73552
Canis familiaris ICAM2 VGNC VGNC:55612
Mus musculus ICAM2 MGD MGI:96394
Rattus norvegicus ICAM2 RGD RGD:1359660
Others ICAM2 NCBI