2. Recombinant Proteins
  3. CD Antigens Complement System
  4. B Cell CD Proteins Epithelial cell CD Proteins Complement Receptor
  5. CD21/CR2 Complement Receptor 2
  6. CD21 Protein, Mouse (HEK293, His)

CD21 Protein, Mouse (HEK293, His)

Cat. No.: HY-P77602
Handling Instructions

CD21 protein, as a receptor for complement C3d and HNRNPU, plays a crucial role in B lymphocyte activation. It forms complexes with CD19, CR2/CD21, CD81 and IFITM1/CD225 and contributes to immune responses. CD21 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD21 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD21 Protein, Mouse (HEK293, His) is 952 a.a., with molecular weight of 130-150 kDa.

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Description

CD21 protein, as a receptor for complement C3d and HNRNPU, plays a crucial role in B lymphocyte activation. It forms complexes with CD19, CR2/CD21, CD81 and IFITM1/CD225 and contributes to immune responses. CD21 Protein, Mouse (HEK293, His) is the recombinant mouse-derived CD21 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD21 Protein, Mouse (HEK293, His) is 952 a.a., with molecular weight of 130-150 kDa.
Background

CD21 Protein, functioning as a receptor for complement C3d and HNRNPU, is integral to the activation of B lymphocytes. Through interactions with C3 and CD19, CD21 participates in immune responses and forms part of a complex that includes CD19, CR2/CD21, CD81, and IFITM1/CD225 in the membrane of mature B-cells. The intricate network of interactions, specifically via Sushi domains 1 and 2, emphasizes CD21's role in modulating immune signaling. Additionally, CD21 associates with FCER2, specifically through the C-terminus, highlighting its involvement in various cellular processes and underscoring its significance in B-cell activation and immune regulation.
Species

Mouse
Source

HEK293
Tag

C-His
Accession

P19070 (I12-W963)
Gene ID

12902  [NCBI]
Molecular Construction
N-term
CD21 (I12-W963)
Accession # P19070
His
C-term
Synonyms
EBV receptor; CD21; C3DR; CR2; C3DRSLEB9; CVID7; SLEB9
Molecular Weight

130-150 kDa
Purity

Greater than 95% as determined by Tris-Bis PAGE
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

CD21 Protein, Mouse (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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