Cr2 - complement receptor 2 Gene

Also Known as Cr1; C3DR; CD21; CD35; Cr-1; Cr-2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12902

Summary

Enables Complement Receptor activity. Acts upstream of or within with a negative effect on complement activation, alternative pathway. Acts upstream of or within several processes, including cellular response to lipopolysaccharide; immunoglobulin mediated immune response; and skeletal system development. Located in external side of plasma membrane. Human ortholog(s) of this gene implicated in common variable immunodeficiency; nasopharynx carcinoma; and systemic lupus erythematosus. Orthologous to human CR2 (complement C3d receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Cr2 Products (2)

mRNA Protein Name
NM_001368765.1 NP_001355694.1 complement receptor type 2 isoform 1 precursor
NM_007758.3 NP_031784.1 complement receptor type 2 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables complement receptor activity IMP
IMP: Inferred from mutant phenotype
11728339 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
11728339 MGI
enables signaling receptor activity IDA
IDA: Inferred from direct assay
11728339 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within bone development IGI
IGI: Inferred from genetic interaction
19828624 MGI
acts upstream of or within cartilage development IGI
IGI: Inferred from genetic interaction
19828624 MGI
acts upstream of or within cellular response to lipopolysaccharide IGI
IGI: Inferred from genetic interaction
19828624 MGI
acts upstream of or within negative effect complement activation, alternative pathway IGI
IGI: Inferred from genetic interaction
19828624 MGI
acts upstream of or within immunoglobulin mediated immune response IGI
IGI: Inferred from genetic interaction
19828624 MGI
acts upstream of or within inflammatory response IGI
IGI: Inferred from genetic interaction
19828624 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
8041705 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

complement receptor type 2

  • complement C3d receptor

  • complement receptor type 1

  • expressed in B lymphocytes

Recombinant Cr2 Proteins

Cat. No. Product Name Accession Purity
HY-P77602 CD21 Protein, Mouse (HEK293, His) P19070 (I12-W963) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N12760 Lobophorin CR-2 / Unkown
HY-RS03133 CR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18588 Cr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25073 Cr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cr2 NCBI NCBI:1380