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  4. CLDN18-VLPs Protein, Human (HEK293, mCherry)

CLDN18-VLPs Protein, Human (HEK293, mCherry)

Cat. No.: HY-P702247
Handling Instructions

CLDN18-VLPs (Claudin 18 virus-like particles) play a crucial role in alveolar fluid homeostasis by modulating tight junction composition, affecting ion transport and solute permeability. They contribute to alveolarization and the paracellular epithelial barrier, affecting epithelial progenitor cell proliferation and organ size by controlling YAP1 subcellular localization. CLDN18-VLPs Protein, Human (HEK293, mCherry) is the recombinant human-derived CLDN18-VLPs protein, expressed by HEK293 , with labeled tag. The total length of CLDN18-VLPs Protein, Human (HEK293, mCherry) is 261 a.a., with molecular weight of 52.3 kDa.

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Description

CLDN18-VLPs (Claudin 18 virus-like particles) play a crucial role in alveolar fluid homeostasis by modulating tight junction composition, affecting ion transport and solute permeability. They contribute to alveolarization and the paracellular epithelial barrier, affecting epithelial progenitor cell proliferation and organ size by controlling YAP1 subcellular localization. CLDN18-VLPs Protein, Human (HEK293, mCherry) is the recombinant human-derived CLDN18-VLPs protein, expressed by HEK293 , with labeled tag. The total length of CLDN18-VLPs Protein, Human (HEK293, mCherry) is 261 a.a., with molecular weight of 52.3 kDa.
Background

CLDN18-VLPs (Claudin 18 virus-like particles) play a crucial role in alveolar fluid homeostasis by regulating the composition of tight junctions in alveolar epithelial cells, impacting ion transport, and solute permeability, potentially through the modulation of actin cytoskeleton organization and beta-2-adrenergic signaling. Essential for lung alveolarization and the maintenance of the paracellular alveolar epithelial barrier, CLDN18-VLPs contribute to epithelial progenitor cell proliferation and organ size regulation by controlling the subcellular localization of YAP1 and restricting its target gene transcription. Additionally, CLDN18-VLPs act as a negative regulator of RANKL-induced osteoclast differentiation, possibly by influencing the subcellular distribution of TJP2/ZO-2 and participating in bone resorption in response to calcium deficiency. They mediate the osteoprotective effects of estrogen independently of RANKL signaling pathways. Furthermore, CLDN18-VLPs are implicated in maintaining the alveolar microenvironment homeostasis by regulating pH and subsequent T-cell activation, indirectly contributing to the limitation of C. neoformans infection.
Species

Human
Source

HEK293
Accession

P56856 (M1-V261)
Gene ID

51208
Synonyms
Claudin-18
AA Sequence

MSTTTCQVVAFLLSILGLAGCIAATGMDMWSTQDLYDNPVTSVFQYEGLWRSCVRQSSGFTECRPYFTILGLPAMLQAVRALMIVGIVLGAIGLLVSIFALKCIRIGSMEDSAKANMTLTSGIMFIVSGLCAIAGVSVFANMLVTNFWMSTANMYTGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLAPEETNYKAVSYHASGHSVAYKPGGFKASTGFGSNTKNKKIYDGGARTEDEVQSYPSKHDYV

Molecular Weight

52.3 kDa
Purity

/
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

CLDN18-VLPs Protein, Human (HEK293, mCherry) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
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