CNTFR alpha Protein, Rat (sf9, His)
The CNTFR alpha protein is essential for binding to ciliary neurotrophic factor (CNTF), ensuring receptor specificity through its alpha subunit. It forms a heterotrimeric complex with LIFR and IL6ST to form a functional receptor. CNTFR alpha Protein, Rat (sf9, His) is the recombinant rat-derived CNTFR alpha protein, expressed by Sf9 insect cells , with C-His labeled tag.
- Species: Rat
- Source: Sf9 insect cells
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The CNTFR alpha protein is essential for binding to ciliary neurotrophic factor (CNTF), ensuring receptor specificity through its alpha subunit. It forms a heterotrimeric complex with LIFR and IL6ST to form a functional receptor. CNTFR alpha Protein, Rat (sf9, His) is the recombinant rat-derived CNTFR alpha protein, expressed by Sf9 insect cells , with C-His labeled tag.
Background
The CNTFR alpha protein plays a crucial role in binding to ciliary neurotrophic factor (CNTF), with its alpha subunit providing receptor specificity. It forms a heterotrimeric complex with LIFR and IL6ST, contributing to the assembly of a functional receptor. Additionally, CNTFR alpha interacts with the heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1. Notably, whether in isolation or in conjunction with the CLCF1-CRLF1 heterodimer, CNTFR alpha engages with SORL1, potentially facilitating internalization and lysosomal degradation through this interaction.
Technical Parameters
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Species Rat
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Source Sf9 insect cells
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Tag C-His
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Accession
Q08406 (Q23-P346)
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Molecular Construction
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N-term
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CNTFR alpha (Q23-P346)
Accession # Q08406 -
His
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C-term
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Protein Length
Partial
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Synonyms
CNTFR; CNTF Receptor Subunit Alpha; Ciliary Neurotrophic Factor Receptor; CNTFR-Alpha; Ciliary Neurotrophic Factor Receptor Subunit Alpha
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AA Sequence
QKHSPQEAPHVQYERLGTDVTLPCGTASWDAAVTWRVNGTDLAPDLLNGSQLILRSLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPKGFYCSWHLSAPTYIPNTFNVTVLHGSKMMVCEKDPALKNRCHIRYMHLFSTIKYKVSISVSNALGHNTTAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSNGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHATPWTEEPRHLTTEAQAPETTTSTTSSLAPPPTTKICDPGELSSGGGP
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Predicted Molecular Mass
39.6 kDa
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Molecular Weight
Approximately 48 kDa, based on SDS-PAGE under reducing conditions.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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