CNTFR alpha Protein, Rat (sf9, His)

The CNTFR alpha protein is essential for binding to ciliary neurotrophic factor (CNTF), ensuring receptor specificity through its alpha subunit. It forms a heterotrimeric complex with LIFR and IL6ST to form a functional receptor. CNTFR alpha Protein, Rat (sf9, His) is the recombinant rat-derived CNTFR alpha protein, expressed by Sf9 insect cells , with C-His labeled tag.

The CNTFR alpha protein plays a crucial role in binding to ciliary neurotrophic factor (CNTF), with its alpha subunit providing receptor specificity. It forms a heterotrimeric complex with LIFR and IL6ST, contributing to the assembly of a functional receptor. Additionally, CNTFR alpha interacts with the heterodimeric neurotropic cytokine composed of CLCF1/CLC and CRLF1/CLF-1. Notably, whether in isolation or in conjunction with the CLCF1-CRLF1 heterodimer, CNTFR alpha engages with SORL1, potentially facilitating internalization and lysosomal degradation through this interaction.

Rat

Sf9 insect cells

C-His

Q08406 (Q23-P346)

313173  [NCBI]

Partial

QKHSPQEAPHVQYERLGTDVTLPCGTASWDAAVTWRVNGTDLAPDLLNGSQLILRSLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPKGFYCSWHLSAPTYIPNTFNVTVLHGSKMMVCEKDPALKNRCHIRYMHLFSTIKYKVSISVSNALGHNTTAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSNGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHATPWTEEPRHLTTEAQAPETTTSTTSSLAPPPTTKICDPGELSSGGGP

Approximately 48 kDa,based on SDS-PAGE under reducing conditions.

≥ 95%, as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.