CSPG5 Protein, Human (HEK293, His)

The CSPG5 protein is a potential growth and differentiation factor that is actively involved in and critical for neural development. It may induce ERBB3 activation, a key pathway for cell growth and differentiation. CSPG5 Protein, Human (HEK293, His) is the recombinant human-derived CSPG5 protein, expressed by HEK293 , with C-His labeled tag.

The CSPG5 protein emerges as a potential growth and differentiation factor, actively participating in neuritogenesis, a critical process in neural development. CSPG5 may exert its influence by inducing the activation of ERBB3, a key signaling pathway involved in cellular growth and differentiation. Additionally, CSPG5 exhibits binding affinity for TNR and likely TNC, suggesting potential interactions with extracellular matrix components. Furthermore, CSPG5 interacts with ERBB3 and GOPC, implicating its involvement in complex cellular signaling networks. Notably, the interaction with MDK, independent of chondroitin sulfate chains, promotes the elongation of oligodendroglial precursor-like cells, underscoring its role in supporting neural cell differentiation. These findings highlight the multifaceted nature of CSPG5 in orchestrating key events during neural development and neuritogenesis. Further exploration is warranted to elucidate the specific molecular mechanisms and downstream pathways through which CSPG5 contributes to these processes.

Human

HEK293

C-8*His

O95196-1 (V31-C423)

10675  [NCBI]

Extracellular Domain

VPAREAGSAVEAEELVKGSPAWEPPANDTREEAGPPAAGEDEASWTAPGGELAGPEEVLQESAAVTGTAWLEADSPGLGGVTAEAGSGDAQALPATLQAPHEVLGQSIMPPAIPEATEASGPPSPTPGDKLSPASELPKESPLEVWLNLGGSTPDPQGPELTYPFQGTLEPQPASDIIDIDYFEGLDGEGRGADLGSFPGSPGTSENHPDTEGETPSWSLLDLYDDFTPFDESDFYPTTSFYDDLDEEEEEEEDDKDAVGGGDLEDENELLVPTGKPGLGPGTGQPTSRWHAVPPQHTLGSVPGSSIALRPRPGEPGRDLASSENGTECRSGFVRHNGSCRSVCDLFPSYCHNGGQCYLVENIGAFCRCNTQDYIWHKGMRCESIITDFQVMC

Approximately 52-62 kDa,based on SDS-PAGE under reducing conditions,due to the glycosylation.

≥ 95%, as determined by Bis-Tris PAGE.

<1 EU/μg, determined by LAL method.