DC-SIGN/CD209 Protein, Mouse (HEK293, His)

DC-SIGN/CD209 Protein, a probable pathogen-recognition receptor, mediates the endocytosis and lysosomal degradation of pathogens. It recognizes high mannose N-linked oligosaccharides in pathogen antigens in a calcium-dependent manner and functions as a receptor for ICAM3, potentially through binding to mannose-like carbohydrates. DC-SIGN/CD209 Protein, Mouse (HEK293, His) is the recombinant mouse-derived DC-SIGN/CD209 protein, expressed by HEK293 , with N-His labeled tag. The total length of DC-SIGN/CD209 Protein, Mouse (HEK293, His) is 252 a.a., with molecular weight of ~40 kDa.

DC-SIGN/CD209 Protein is a probable pathogen-recognition receptor that functions in the endocytosis of pathogens, leading to their degradation in lysosomal compartments. It is capable of recognizing high mannose N-linked oligosaccharides in various pathogen antigens in a calcium-dependent manner. Additionally, it acts as a receptor for ICAM3, likely through its binding to mannose-like carbohydrates.

Mouse

HEK293

N-His

Q8CJ91 (Q74-G325)

69165  [NCBI]

Approximately 40 kDa

Greater than 95% as determined by reducing SDS-PAGE

Lyophilized powder.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.