DLG4 Protein, Human (Biotinylated, Avi)

DLG4 is a postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. It interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels and is required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 alters the ratio of excitatory to inhibitory synapses in hippocampal neurons. It may reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly and may regulate the intracellular trafficking of ADR1B. Additionally, DLG4 regulates AMPA-type glutamate receptor (AMPAR) immobilization at the postsynaptic density, maintaining the channels in an activated state in the presence of glutamate and preventing synaptic depression (by similar). Under basal conditions, DLG4 cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and subsequent inhibition of its association with endocytic proteins.