EphB1 Protein, Mouse (Active, sf9, His-GST)

EphB1 protein is a receptor tyrosine kinase that binds to ephrin-B ligands on neighboring cells, resulting in contact-dependent bidirectional signaling. This receptor mediates both forward signaling and reverse signaling pathways. Its ligands include EFNB1, EFNB2, and EFNB3, which play important roles in various cellular processes. During nervous system development, EphB1 regulates retinal axon guidance and interacts with EFNB2. In the adult nervous system, it works together with EFNB3 to regulate chemotaxis, proliferation, and polarity of neural progenitors. EphB1 is also involved in dendritic spine maturation, synapse formation, angiogenesis, targeted cell migration, and adhesion. Activation by EFNB1 and other ephrin-B ligands activates MAPK/ERK and JNK signaling pathways, which regulate cell migration and adhesion. Additionally, EphB1 is important for maintaining the pool of muscle stem cells (satellite cells) by promoting self-renewal and reducing activation and differentiation.