Ephb1 - Eph receptor B1 Gene

Also Known as Elk; Net; Cek6; Elkh; Hek6; 9330129L11; C130099E04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 270190

Summary

Enables axon guidance receptor activity. Involved in several processes, including dendritic spine morphogenesis; detection of temperature stimulus involved in sensory perception of pain; and negative regulation of satellite cell differentiation. Acts upstream of or within several processes, including axonogenesis; Ephrin Receptor signaling pathway; and optic nerve morphogenesis. Located in several cellular components, including axon; filopodium tip; and membrane raft. Is active in glutamatergic synapse. Is expressed in several structures, including 1st branchial arch; brain; lower urinary tract; sensory organ; and vascular system. Orthologous to human EphB1 (EPH receptor B1). [provided by Alliance of Genome Resources, Apr 2022]

Ephb1 Products (2)

mRNA Protein Name
NM_001168296.1 NP_001161768.1 ephrin type-B receptor 1 isoform 2 precursor
NM_173447.3 NP_775623.3 ephrin type-B receptor 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables axon guidance receptor activity IDA
IDA: Inferred from direct assay
11532925 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12925710 MGI
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
17310244 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within axon guidance IDA
IDA: Inferred from direct assay
11532925 MGI
acts upstream of or within axon guidance IMP
IMP: Inferred from mutant phenotype
12971893 MGI
acts upstream of or within camera-type eye morphogenesis IMP
IMP: Inferred from mutant phenotype
12971893 MGI
involved in cell chemotaxis IMP
IMP: Inferred from mutant phenotype
18057206 MGI
acts upstream of or within central nervous system projection neuron axonogenesis IDA
IDA: Inferred from direct assay
12971893 MGI
acts upstream of or within central nervous system projection neuron axonogenesis IMP
IMP: Inferred from mutant phenotype
12971893 MGI
acts upstream of or within cranial nerve development IMP
IMP: Inferred from mutant phenotype
12971893 MGI
involved in dendritic spine development IMP
IMP: Inferred from mutant phenotype
14691139 MGI
acts upstream of or within dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
17310244 MGI
involved in dendritic spine morphogenesis IMP
IMP: Inferred from mutant phenotype
14691139 MGI
involved in detection of temperature stimulus involved in sensory perception of pain IMP
IMP: Inferred from mutant phenotype
19025592 MGI
acts upstream of or within ephrin receptor signaling pathway IDA
IDA: Inferred from direct assay
17310244 MGI
involved in establishment of cell polarity IMP
IMP: Inferred from mutant phenotype
18057206 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
19523204 MGI
involved in modulation of chemical synaptic transmission IEP
IEP: Inferred from expression pattern
19523204 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
19523204 MGI
involved in negative regulation of satellite cell differentiation IMP
IMP: Inferred from mutant phenotype
27446912 MGI
involved in negative regulation of skeletal muscle satellite cell proliferation IMP
IMP: Inferred from mutant phenotype
27446912 MGI
involved in neural precursor cell proliferation IMP
IMP: Inferred from mutant phenotype
18057206 MGI
involved in neurogenesis IMP
IMP: Inferred from mutant phenotype
18057206 MGI
acts upstream of or within optic nerve morphogenesis IMP
IMP: Inferred from mutant phenotype
12971893 MGI
involved in positive regulation of synapse assembly IMP
IMP: Inferred from mutant phenotype
14691139 MGI
acts upstream of or within retinal ganglion cell axon guidance IDA
IDA: Inferred from direct assay
12971893 MGI
involved in skeletal muscle satellite cell activation IMP
IMP: Inferred from mutant phenotype
27446912 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
16701205 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
12093895 MGI
located in filopodium tip IDA
IDA: Inferred from direct assay
24305805 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
19523204 MGI
is active in glutamatergic synapse IEP
IEP: Inferred from expression pattern
19523204 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
19523204 MGI
located in membrane IDA
IDA: Inferred from direct assay
12093895 MGI
located in membrane raft IDA
IDA: Inferred from direct assay
15502157 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ephrin type-B receptor 1

Recombinant Ephb1 Proteins

Cat. No. Product Name Accession Purity
HY-P75747 EphB1 Protein, Mouse (Active, sf9, His-GST) Q8CBF3-1 (M591-A984) ≥ 80%, as determined by reducing SDS-PAGE.
HY-P75748 EphB1 Protein, Mouse (HEK293, His) Q8CBF3-1 (M18-L539) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-115481 EphB1-IN-1 Inhibitor 99.51% Unkown
HY-170517 PKMYT1-IN-8 Inhibitor 99.31% Unkown
HY-179572 STA-013 99.18% Unkown
HY-10654 EphB4-IN-2 Inhibitor / Unkown
HY-183103 PDD-87 Inhibitor / Unkown
HY-RS04433 EPHB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183909 EphB1-IN-2 Inhibitor / Unkown
HY-RS18062 Ephb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24537 Ephb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ephb1 NCBI NCBI:2047