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Cat. No.: HY-115481
Handling Instructions

EphB1-IN-1 (Compound 1) is a potent EphB1 inhibitor with IC50s of 3.0, 15 and 220 nM against EphB1G703C, EphB1T697G and EphB1WT, respectively.

For research use only. We do not sell to patients.

EphB1-IN-1 Chemical Structure

EphB1-IN-1 Chemical Structure

CAS No. : 1980036-18-7

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EphB1-IN-1 (Compound 1) is a potent EphB1 inhibitor with IC50s of 3.0, 15 and 220 nM against EphB1G703C, EphB1T697G and EphB1WT, respectively[1].

IC50 & Target

IC50: 3.0 nM (EphB1G703C), 15 nM (EphB1T697G), 220 nM (EphB1WT)[1]

In Vitro

EphB1-IN-1 (Compound 1) and 3MB-PP1 (HY-102069) cause orthogonal inhibition of two Eph kinases in the same cell[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HEK293 cells
Concentration: 300 nM
Incubation Time:
Result: Inhibited EphB1G703C. Abolished the autophosphorylation of EphB3WT with little effect on that of EphB1T697G. 100 nM of 3MB-PP1 abolished the autophosphorylation of EphB1T697G but had little effect on that of EphB3WT.
Molecular Weight







Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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