2. Gene
  3. EPHB1 - EPH receptor B1 Gene

EPHB1 - EPH receptor B1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ELK; NET; Hek6; EPHT2

Gene ID: 2047 | Gene type: protein coding

About EPHB1

Cytogenetic location: 3q22.2 Genomic coordinates (GRCh38): 3:134,795,260-135,260,467 (from NCBI)

This gene has 9 transcripts (splice variants), 238 orthologues and 53 paralogues. Biased expression in brain (RPKM 6.3), testis (RPKM 3.5) and 8 other tissues.

Summary

Ephrin receptors and their ligands, the Ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, Ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008]

EPHB1 Products(1)

mRNA Protein Name
NM_004441.5 NP_004432.1 ephrin type-B receptor 1 precursor

EPHB1 Protein Structure

Ephrin_lbd

Ephrin_lbd: Ephrin receptor ligand binding domain (19 - 196)

fn3

fn3: Fibronectin type III domain (326 - 415)

fn3

fn3: Fibronectin type III domain (440 - 518)

EphA2_TM

EphA2_TM: Ephrin type-A receptor 2 transmembrane domain (542 - 616)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (620 - 878)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (911 - 973)

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  • 984 a.a.
Protein Preferred Names Protein Names

ephrin type-B receptor 1

EK6

Recombinant EPHB1 Proteins

Cat. No. Product Name Accession Purity
HY-P70381 EphB1 Protein, Human (HEK293, Fc) P54762 (M18-P540) ≥95%
HY-P70177 EphB1 Protein, Human (421a.a, HEK293, His) P54762 (S564-A984) ≥95%
HY-P72997 EphB1 Protein, Human (sf9, His-GST) P54762 (R565-A984) ≥95%
HY-P72998 EphB1 Protein, Human (540a.a, HEK293, His) P54762 (M1-P540) ≥95%

Related Diseases

Diseases Alias
Craniofrontonasal Syndrome

Craniofrontonasal Dysplasia

CFNS

Cfnd

Craniofrontonasal Dysostosis

Craniofrontonasal Dystosis

Dysplasia, Craniofrontonasal
Ovary Serous Adenocarcinoma

Malignant Ovarian Serous Tumor

Serous Carcinoma Of Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-115481 EphB1-IN-1 Inhibitor 99.87% Unkown
HY-RS04433 EPHB1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta EPHB1 VGNC VGNC:72241
Canis familiaris EPHB1 VGNC VGNC:49889
Bos taurus EPHB1 VGNC VGNC:50173
Mus musculus EPHB1 MGD MGI:1096337
Rattus norvegicus EPHB1 RGD RGD:2556
Felis catus EPHB1 VGNC VGNC:61906
Others EPHB1 NCBI