EPHB1 - EPH receptor B1 Gene

Also Known as ELK; NET; Hek6; EPHT2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2047

About EPHB1

Cytogenetic location: 3q22.2 Genomic coordinates (GRCh38): 3:134,795,260-135,260,467 (from NCBI)

This gene has 9 transcripts (splice variants), 238 orthologues and 53 paralogues. Biased expression in brain (RPKM 6.3), testis (RPKM 3.5) and 8 other tissues.

Summary

Ephrin receptors and their ligands, the Ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, Ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008]

EPHB1 Products (1)

mRNA Protein Name
NM_004441.5 NP_004432.1 ephrin type-B receptor 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
8798570 GOA
enables transmembrane-ephrin receptor activity IDA
IDA: Inferred from direct assay
18034775 GOA
Biological Process GO Annotation Evidence References Source
involved in angiogenesis IDA
IDA: Inferred from direct assay
9499402 GOA
involved in cell chemotaxis IDA
IDA: Inferred from direct assay
12925710 GOA
involved in cell-substrate adhesion IDA
IDA: Inferred from direct assay
9430661 GOA
involved in ephrin receptor signaling pathway IDA
IDA: Inferred from direct assay
12925710 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
18034775 GOA
involved in regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
12925710 GOA
involved in regulation of JNK cascade IDA
IDA: Inferred from direct assay
9430661 GOA
Cellular Component GO Annotation Evidence References Source
located in early endosome membrane IDA
IDA: Inferred from direct assay
18034775 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
18034775 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EPHB1 Protein Structure

Ephrin_lbd

Ephrin_lbd: Ephrin receptor ligand binding domain (19 - 196)

fn3

fn3: Fibronectin type III domain (326 - 415)

fn3

fn3: Fibronectin type III domain (440 - 518)

EphA2_TM

EphA2_TM: Ephrin type-A receptor 2 transmembrane domain (542 - 616)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (620 - 878)

SAM_1

SAM_1: SAM domain (Sterile alpha motif) (911 - 973)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 984 a.a.
Protein Preferred Names Protein Names

ephrin type-B receptor 1

  • EK6

EPHB1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EPHB1 P54762 GRB2 Homo sapiens P62993
CoIP
8798570
Intra
EPHB1 P54762 GRB10 Homo sapiens Q13322
CoIP
8798570
Intra
EPHB1 P54762 GRB7 Homo sapiens Q14451
Pull Down
12223469
Intra
EPHB1 P54762 GRB7 Homo sapiens Q14451
Y2H
12223469
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EPHB1 Proteins

Cat. No. Product Name Accession Purity
HY-P70381 EphB1 Protein, Human (HEK293, Fc) P54762-1 (M18-P540) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72997 EphB1 Protein, Human (Active, sf9, His-GST) AAI11745.1 (R565-A984) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72998 EphB1 Protein, Human (HEK293, His) P54762-1 (M18-P540) ≥ 95%, as determined by reducing SDS-PAGE.

EPHB1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82431 Ephrin Receptor B1 Antibody (YA2176) WB, IP Human, Mouse, Rat
HY-P85145 Ephrin Receptor B1 Antibody (YA4837) WB, IHC-P, ICC/IF, ELISA Human

Related Diseases

Diseases Alias
Craniofrontonasal Syndrome

  • Craniofrontonasal Dysplasia

  • CFNS

  • Cfnd

  • Craniofrontonasal Dysostosis

  • Craniofrontonasal Dystosis

  • Dysplasia, Craniofrontonasal
Ovary Serous Adenocarcinoma

  • Malignant Ovarian Serous Tumor

  • Serous Carcinoma Of Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-115481 EphB1-IN-1 Inhibitor 99.51% Unkown
HY-170517 PKMYT1-IN-8 Inhibitor 99.31% Unkown
HY-179572 STA-013 99.18% Unkown
HY-10654 EphB4-IN-2 Inhibitor / Unkown
HY-183103 PDD-87 Inhibitor / Unkown
HY-RS04433 EPHB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183909 EphB1-IN-2 Inhibitor / Unkown
HY-RS18062 Ephb1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24537 Ephb1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta EPHB1 VGNC VGNC:72241
Canis familiaris EPHB1 VGNC VGNC:49889
Bos taurus EPHB1 VGNC VGNC:50173
Mus musculus EPHB1 MGD MGI:1096337
Rattus norvegicus EPHB1 RGD RGD:2556
Felis catus EPHB1 VGNC VGNC:61906
Others EPHB1 NCBI