FZD3 Protein, Human (Cell-Free, His)

FZD3, serving as a receptor for Wnt proteins, primarily engages in the beta-catenin canonical signaling pathway, orchestrating the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin, and induction of Wnt target genes. A secondary signaling pathway involving PKC and calcium fluxes, observed in certain family members, raises questions about its distinct nature and potential integration with the canonical pathway, given the crucial role of PKC in Wnt-mediated GSK-3 kinase inactivation. Interactions with G-proteins are integral to both pathways. Wnt5A activation stimulates PKC activity through a G-protein-dependent mechanism. FZD3 is implicated in transducing polarity information during tissue morphogenesis and differentiated tissues, playing a critical role in controlling early axon growth and guidance processes. It is essential for the development of major fiber tracts in the central nervous system and regulates axon growth in specific populations of cranial and spinal motor neurons. Additionally, FZD3 is involved in the migration of cranial neural crest cells and contributes to the transmission of sensory information. It collaborates with FZD6 in neural tube closure and participates in establishing planar cell polarity, particularly in orienting stereocilia bundles in auditory and vestibular sensory cells. Furthermore, FZD3 promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle through a beta-catenin-dependent mechanism. Interactions with VANGL2 further underscore its multifaceted role in cellular processes.