Frizzled-3
Among the ten Frizzled Wnt receptors, Frizzled-3 (FZD3) stands out for its prominent role in the nervous system. Its extracellular CRD binds several Wnt ligands, and signaling proceeds largely through non-canonical planar cell polarity effectors rather than robust beta-catenin activation. Fzd3-deficient mice show defective neural tube closure, abnormal axon trajectories and impaired commissure formation, and the receptor guides neural crest cell migration and cranial nerve patterning during embryogenesis. In adults, FZD3 expression persists in the brain and is also detected in endothelial cells of the blood-brain barrier. Because dysregulated FZD3 expression correlates with progression in cancers such as colorectal carcinoma and neuroblastoma, it is being evaluated as a therapeutic antibody target.
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Frizzled-3 Recombinant Proteins (1)
- Species:
- Source:
Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formel: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
