1. Recombinant Proteins
  2. Viral Proteins
  3. envelope glycoprotein gp120 Protein, SIV (ADN41251, HEK293, His)

envelope glycoprotein gp120 Protein, SIV (ADN41251, HEK293, His)

Cat. No.: HY-P75159
Handling Instructions

envelope glycoprotein gp120 Protein is a glycoprotein exposed on the surface of the HIV envelope. Gp120 is essential for viral infection as it facilitates HIV entry into the host cell. gp120 may also be facilitating viral persistence and continuing HIV infection by influencing the T cell immune response to the virus. envelope glycoprotein gp120 Protein, SIV (ADN41251, HEK293, His) is the recombinant Virus-derived envelope glycoprotein gp120 protein, expressed by HEK293 , with C-His labeled tag. The total length of envelope glycoprotein gp120 Protein, SIV (ADN41251, HEK293, His) is 509 a.a., with molecular weight of ~60 kDa.

For research use only. We do not sell to patients.

Protein Expression Service

Size Stock
50 μg   Get quote  
100 μg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

envelope glycoprotein gp120 Protein is a glycoprotein exposed on the surface of the HIV envelope. Gp120 is essential for viral infection as it facilitates HIV entry into the host cell. gp120 may also be facilitating viral persistence and continuing HIV infection by influencing the T cell immune response to the virus. envelope glycoprotein gp120 Protein, SIV (ADN41251, HEK293, His) is the recombinant Virus-derived envelope glycoprotein gp120 protein, expressed by HEK293 , with C-His labeled tag. The total length of envelope glycoprotein gp120 Protein, SIV (ADN41251, HEK293, His) is 509 a.a., with molecular weight of ~60 kDa.

Background

envelope glycoprotein gp120 (gp120) is a glycoprotein exposed on the surface of the HIV envelope. Gp120 is essential for viral infection as it facilitates HIV entry into the host cell and it plays a vital role in attachment to specific cell surface receptors. These receptors are DC-SIGN, Heparan Sulfate Proteoglycan and a specific interaction with the CD4 receptor, particularly on helper T-cells. gp120 may also be facilitating viral persistence and continuing HIV infection by influencing the T cell immune response to the virus. Several mechanisms may be involved in this process of which gp120 binds to the CD4 receptor of T cells which facilitates viral entry into the CD4+ cells and their depletion. Gp120 is shed from the viral membrane and accumulates in lymphoid tissues in significant amounts. It can induce apoptosis and severely alter the immune response to the virus by dampening the antiviral CTL response thus impeding the clearance of HIV[1].

Species

Virus

Source

HEK293

Tag

C-His

Accession

ADN41251 (I20-R528)

Gene ID

/

Molecular Construction
N-term
HIV-1 gp160 (I20-R528)
Accession # ADN41251
His
C-term
Synonyms
Simian immunodeficiency virus (SIV) (isolate 216.94.A2) gp120 Protein
Molecular Weight

Approximately 60 kDa

Purity

Greater than 90% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

envelope glycoprotein gp120 Protein, SIV (ADN41251, HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
envelope glycoprotein gp120 Protein, SIV (ADN41251, HEK293, His)
Cat. No.:
HY-P75159
Quantity:
MCE Japan Authorized Agent: