IFN-alpha 17/IFNA17 Protein, Human (His)
Based on 1 Customer Validation
IFN-alpha 17 (IFNA17) is an antivirus drug. Type I Interferons (INFαs and INF β) are proinflammatory cytokines that promote atherosclerosis. IFNα, a cytokine with multiple functions in innate and adaptive immunity and a potent inhibitor of HIV, exerts antiviral activity. IFN-alpha 17/IFNA17 Protein, Human (His) is the recombinant human-derived IFN-alpha 17/IFNA17 protein, expressed by E. coli , with N-6*His tag.
- Species: Human
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
IFN-alpha 17 (IFNA17) is an antivirus drug. Type I Interferons (INFαs and INF β) are proinflammatory cytokines that promote atherosclerosis. IFNα, a cytokine with multiple functions in innate and adaptive immunity and a potent inhibitor of HIV, exerts antiviral activity[1][2][3]. IFN-alpha 17/IFNA17 Protein, Human (His) is the recombinant human-derived IFN-alpha 17/IFNA17 protein, expressed by E. coli , with N-6*His tag.
Background
IFNs are named after their ability to “interfere” with viral replication within host cells. IFNs are presently classified into three groups: type I, type II, and type III. The type I IFNs include all IFNαs, IFNβ, IFNε, IFNκ, IFNω, and IFNν. IFNα, a cytokine with multiple functions in innate and adaptive immunity and a potent inhibitor of HIV, exerts antiviral activity, in part, by enhancing apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3 (APOBEC3) family members. The genes for type I interferon (IFN), which include 14 IFN-alpha genes, 1 IFN-beta gene, 1 IFN-omega gene, and a number of IFN-omega pseudogenes, are clustered on human chromosome 9[1][2][3].
MCE Validation Data
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Purity - SDS-PAGE
Purity - SDS-PAGE
Technical Parameters
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Species Human
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Source E. coli
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Tag N-6*His
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Accession
P01571 (C24-D189)
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Gene ID3451 [NCBI]
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Molecular Construction
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N-term
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6*His
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IFNA17 (C24-D189)
Accession # P01571 -
C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
IFNA17; Interferon Alpha-T; Interferon Alpha 17; IFN-Alpha-17; IFN-AlphaI; LeIF I; LEIF2C1; Interferon Alpha-WA; Interferon Alpha-17; Interferon 1AA4; Interferon Alpha-88; IFNA; Interferon Alpha-I'; INFA
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AA Sequence
CDLPQTHSLGNRRALILLAQMGRISPFSCLKDRHDFGLPQEEFDGNQFQKTQAISVLHEMIQQTFNLFSTEDSSAAWEQSLLEKFSTELYQQLNNLEACVIQEVGMEETPLMNEDSILAVRKYFQRITLYLTEKKYSPCAWEVVRAEIMRSLSFSTNLQKILRRKD
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Predicted Molecular Mass
20.1 kDa
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Molecular Weight
Approximately 20 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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