ISM1 Protein, Human (HEK293, His)
ISM1 Protein, an angiogenesis inhibitor, regulates blood vessel formation by interacting with integrin ITGAV/ITGB5. Its participation in modulating integrin-mediated cellular processes emphasizes ISM1's potential significance in finely tuned regulatory networks governing vascular development and homeostasis. ISM1 Protein, Human (HEK293, His) is the recombinant human-derived ISM1 protein, expressed by HEK293 , with N-His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
ISM1 Protein, an angiogenesis inhibitor, regulates blood vessel formation by interacting with integrin ITGAV/ITGB5. Its participation in modulating integrin-mediated cellular processes emphasizes ISM1's potential significance in finely tuned regulatory networks governing vascular development and homeostasis. ISM1 Protein, Human (HEK293, His) is the recombinant human-derived ISM1 protein, expressed by HEK293 , with N-His labeled tag.
Background
ISM1 protein functions as an angiogenesis inhibitor, playing a pivotal role in the regulation of blood vessel formation. Its mechanism involves interaction with integrin ITGAV/ITGB5, suggesting its participation in modulating integrin-mediated cellular processes that are crucial for angiogenesis. The intricate interplay between ISM1 and integrin signaling highlights its potential significance in the finely tuned regulatory networks governing vascular development and homeostasis.
Technical Parameters
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Species Human
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Source HEK293
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Tag N-6*His
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Accession
B1AKI9 (A30-Y464)
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Molecular Construction
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N-term
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6*His
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ISM1 (A30-Y464)
Accession # B1AKI9 -
C-term
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Protein Length
Full Length of Mature Protein
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Synonyms
ISM1; ISM; Prev. C20orf82; Isthmin 1 Homolog (Zebrafish); BA149I18.1; Isthmin 1 Homolog; Isthmin 1, Angiogenesis Inhibitor; DJ1077I2.1; Isthmin-1; Isthmin; Isthmin 1; Chromosome 20 Open Reading Frame 82
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AA Sequence
ADGPDAAAGNASQAQLQNNLNVGSDTTSETSFSLSKEAPREHLDHQAAHQPFPRPRFRQETGHPSLQRDFPRSFLLDLPNFPDLSKADINGQNPNIQVTIEVVDGPDSEADKDQHPENKPSWSVPSPDWRAWWQRSLSLARANSGDQDYKYDSTSDDSNFLNPPRGWDHTAPGHRTFETKDQPEYDSTDGEGDWSLWSVCSVTCGNGNQKRTRSCGYACTATESRTCDRPNCPGIEDTFRTAATEVSLLAGSEEFNATKLFEVDTDSCERWMSCKSEFLKKYMHKVMNDLPSCPCSYPTEVAYSTADIFDRIKRKDFRWKDASGPKEKLEIYKPTARYCIRSMLSLESTTLAAQHCCYGDNMQLITRGKGAGTPNLISTEFSAELHYKVDVLPWIICKGDWSRYNEARPPNNGQKCTESPSDEDYIKQFQEAREY
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Predicted Molecular Mass
53.1 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 500 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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