Kappa-Casein Protein, Human (HEK293, His)
Based on 1 Customer Validation
Kappa-casein (CSN3) is a member of Caseins family, and is an extracellular mammalian milk protein involved in several important physiological processes. CSN3 prevents casein precipitation in milk and increase the efficiency of digestion, prevention of neonate hypersensitivity to ingested proteins, and inhibition of gastric pathogens. Kappa-Casein Protein, Human (HEK293, His) is the recombinant human-derived Kappa-Casein protein, expressed by HEK293 , with C-6*His labeled tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
Kappa-casein (CSN3) is a member of Caseins family, and is an extracellular mammalian milk protein involved in several important physiological processes. CSN3 prevents casein precipitation in milk and increase the efficiency of digestion, prevention of neonate hypersensitivity to ingested proteins, and inhibition of gastric pathogens. Kappa-Casein Protein, Human (HEK293, His) is the recombinant human-derived Kappa-Casein protein, expressed by HEK293 , with C-6*His labeled tag.
Background
Kappa-casein (CSN3) is a member of Caseins family, and is an extracellular mammalian milk protein involved in several important physiological processes. CSN3 stabilizes micelle formation, preventing casein precipitation in milk. Chymosin splits CSN3 into an insoluble peptide (para kappa-casein) and water-soluble glycomacropeptide (GMP). GMP is responsible for an increased efficiency of digestion, prevention of neonate hypersensitivity to ingested proteins, and inhibition of gastric pathogens[1][2].
Technical Parameters
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Species Human
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Source HEK293
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Tag C-6*His
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Accession
AAH10935.1 (E21-A182)
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Molecular Construction
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N-term
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Kappa-Casein (E21-A182)
Accession # AAH10935.1 -
6*His
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C-term
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Protein Length
Full Length of Kappa-casein Chain
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Synonyms
CSN3; Casein, Kappa; Prev. CSN10; CASK; Kappa-Casein; KCA; CSNK; Casein Kappa; CNS10
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AA Sequence
EVQNQKQPACHENDERPFYQKTAPYVPMYYVPNSYPYYGTNLYQRRPAIAINNPCVPRTYYANPAVVRPHAQIPQRQYLPNSHPPTVVRRPNLHPSFIAIPPKKIQDKIIIPTINTIATVEPTPAPATEPTVDSVVTPEAFSESIITSTPETTTVAVTPPTA
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Predicted Molecular Mass
19.1 kDa
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Molecular Weight
Approximately 24-36 kDa, based on SDS-PAGE under reducing conditions.
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Glycosylation
Yes
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US;may vary elsewhere.
Documentation
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Data Sheet (235 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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