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CSN3 - casein kappa Gene

Also Known as KCA; CSNK; CNS10; CSN10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1448

About CSN3

Cytogenetic location: 4q13.3 Genomic coordinates (GRCh38): 4:70,238,381-70,251,432 (from NCBI)

This gene has 2 transcripts (splice variants) and 84 orthologues. Restricted expression toward salivary gland (RPKM 13.6).

Summary

Involved in lactation and protein stabilization. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

CSN3 Products (2)

mRNA	Protein	Name
NM_001394997.1	NP_001381926.1	kappa-casein precursor
NM_005212.3	NP_005203.2	kappa-casein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in lactation	IDA IDA: Inferred from direct assay	7979373	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	7979373	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	7979373	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSN3 Protein Structure

Casein_kappa

0
100
182 a.a.

Protein Preferred Names	Protein Names
kappa-casein

CSN3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CSN3	P07498	ZNF76	Homo sapiens	P36508	Validated Y2H	32296183
Intra	CSN3	P07498	RBPMS	Homo sapiens	Q93062	Y2H Array	25416956
Intra	CSN3	P07498	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	32296183
Intra	CSN3	P07498	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	CSN3	P07498	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32296183
Intra	CSN3	P07498	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
Intra	CSN3	P07498	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	CSN3	P07498	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CSN3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70978	Kappa-Casein Protein, Human (HEK293, His)	AAH10935.1 (E21-A182)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Milk Allergy	Milk Allergic Reaction Milk Hypersensitivity Allergy Milk
Food Allergy	Food Hypersensitivity Food Allergies Allergy Food Food Allergen-Induced Hypersensitivity
Mastitis	Breast Inflammation Inflammatory Breast Disease Inflammatory Disease Of Breast Inflammation Of Non-Human Mammary Gland Inflammatory Disorder Of Breast Mastitis Nos Acute Mastitis Nos Acute Nonpuerperal Mastitis Nonpuerperal Mastitis Nos Subacute Mastitis Nos
Cow Milk Allergy	Bos Taurus Milk Allergy Cow'S Milk Protein Sensitivity
Dentin Sensitivity	Sensitive Dentin
Epilepsy, Juvenile Absence 1	Epilepsy, Juvenile Absence, Susceptibility To, 1 EJA1 JAE1 Juvenile Absence Epilepsy 1 Susceptibility To Juvenile Absence Epilepsy 1 Epilepsy, Juvenile Absence, Susceptibility To, Type 1 Absence Epilepsy
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03028	COPS3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS03244	CSN3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown